Results 131 to 140 of about 158,807,029 (257)

Activins in adipogenesis and obesity [PDF]

International Journal of Obesity, 2012
Activins are secreted proteins members of the transforming growth factor-β family. They are involved in many biological responses including regulation of apoptosis, proliferation and differentiation of different cell types. Activins A, B and AB are highly expressed in adipose tissue, and in this review we will illustrate that activins have a role in ...
openaire   +2 more sources

Human iPSC‐Derived Vascularised Lung Organoids for Modelling COPD and Pulmonary Hypertension

Cell Proliferation, EarlyView.
Vascularised lung organoids (vLOs) that faithfully mimic human lung tissue architecture and disease pathology are critical for advancing pulmonary research but remain challenging to generate. Here, we developed a robust self‐organisation protocol to produce vLOs with cellular heterogeneity and functional vasculature. The engineered blood vessels within
Simin Jiang, Liangliang Tian, Jingge Qu, Yi Hong, Dian Chen, Zihang Pan, Huanyu Long, Lanhe Chu, Weijing Kong, Qiyang Yao, Xiaojing Ma, Yun Zhao, Baihui Ma, Kai Wang, Yahong Chen   +14 more
wiley   +1 more source

Inhibin and activin modulate human monocyte chemotaxis and human lymphocyte interferon-gamma production.

, 1991
Inhibin and activin are referred to as gonadal glycoprotein hormones whose function is the control of FSH release from the pituitary gland. However, several observations indicate that inhibin and activin are produced in various organs and serve ...
Genazzani AD, ANGIONI, STEFANO, Muscettola M, Sacerdote P, Grasso G., Petraglia F, Cossarizza A, Franceschi C   +7 more
core   +2 more sources

Elevated serum Activin A in chronic obstructive pulmonary disease with skeletal muscle wasting

Clinics
OBJECTIVE: Muscle wasting contributes to the reduced quality of life and increased mortality in chronic obstructive pulmonary disease (COPD). Muscle atrophy in mice with cachexia was caused by Activin A binding to ActRIIB. The role of circulating Activin
Guanghui Zhou, Xianhua Gui, Ruhua Chen, Xingli Fu, Xiuhai Ji, Hui Ding   +5 more
doaj   +1 more source

BCL2 Facilitates Naïve Pluripotency and an 8C‐Like State in Human Embryonic Stem Cells

Cell Proliferation, EarlyView.
BCL2 stabilizes human naïve pluripotency associated with H3K27ac modulation and induces 8CLCs in human naïve ESCs. ABSTRACT Human naïve embryonic stem cells (ESCs) can spontaneously transition into 8‐cell‐like cells (8CLCs), a cell state that recapitulates the totipotent features of the 8‐cell‐stage embryo.
Zhimin Lu, Han Wu, Xiaomin Su, Hua Yu, Fang Yang, Siqin Bao, Xihe Li, Baojiang Wu   +7 more
wiley   +1 more source

Activin A is deeply involved in the progression of sarcopenia and leads to poor prognosis in lung cancer patients

Scientific Reports
Patients with lung cancer frequently develop sarcopenia, which severely affects quality of life. The underlying mechanisms of lung cancer sarcopenia need to be clarified because sarcopenia is strongly correlated with poor prognosis.
Yo Kawaguchi, Yoko Kataoka, Keigo Okamoto, Makoto Yoden, Takuya Shiratori, Ryosuke Kaku, Keiko Ueda, Yasuhiko Ohshio, Tomoya Terashima, Jun Hanaoka   +9 more
doaj   +1 more source

Weight Regain After Incretin Treatment: The Lean Mass Deficit Hypothesis and a Role for Testosterone Combination Therapy in Men

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), dual glucose‐dependent insulinotropic polypeptide (GIP)/GLP‐1RA and triple (GIP)/GLP‐1RA/glucagon agonists achieve placebo‐subtracted weight loss of 15% to 22%. Their long‐term value depends on how well the weight loss is maintained and on the composition of weight loss, not only
Michael Zitzmann, Zsolt Bosnyak, Richard Jones, Monica Caliber   +3 more
wiley   +1 more source

Epigenetic control of cellular plasticity in breast cancer progression

The FEBS Journal, EarlyView.
Cancer cells undergo cell state transitions, termed plasticity, driving cancer progression and dictating therapeutic response. We define breast cancer plasticity into four interconnected processes: (1) breast cancer stem cell fates, (2) epithelial‐to‐mesenchymal transition, (3) maintenance of luminal identity, and (4) acquisition of therapeutic ...
Ellie J. Massey, Elizabeth Podleszanski, William J. Muller   +2 more
wiley   +1 more source

Identification of ActivinβA and Gonadotropin Regulation of the Activin System in the Ovary of Chinese Sturgeon Acipenser sinensis

Activin is a dimeric growth factor with diverse biological activities in vertebrates. This study aimed to investigate the regulatory role of the activin signaling pathway in the ovary of the endangered, cultured sturgeon species Acipenser sinensis.
Huan Ye, Rui Ruan, Hao Du, Chuangju Li, Huamei Yue   +4 more
core   +1 more source

Variations in activin receptor, inhibin/activin subunit and follistatin mRNAs in human prostate tumour tissues.

, 2000
The possible role of activin in the regulation of malignant prostatic growth was studied using RNAase protection assays of activin receptors, inhibin/activin subunits and follistatin mRNAs in the human prostatic carcinoma cell lines LNCaP-FGC, -R and ...
Schaik, R.H.N. (Ron) van, F H de Jong, C D J Wierikx, Timmerman, MA (Marianna), Kwast, Theodorus, Steenbrugge, G.J. (Gert Jan) van, Wierikx, C.D., Oomen, Monique, Timmerman, M.A. (Marianna), Weerden, W.M. (Wytske) van, Wierikx, CDJ, G J van Steenbrugge, Jong, F.H. (Frank) de, Kwast, Th.H. (Theo) van der, M H Oomen, van Schaik, Ron, Steenbrugge, Gert jan, Jong, Frank, R H N van Schaik, W M van Weerden, van Weerden, Wytske; id_orcid, T H van der Kwast, Oomen, M.H.A. (Monique), M A Timmerman   +23 more
core   +1 more source