Results 151 to 160 of about 158,807,029 (257)

Activin Actions in Adipocytes

The Journal of Clinical Endocrinology & Metabolism
Abstract Obesity is a growing global health problem characterized by excess fat accumulation. Though causes of obesity are multifactorial, glucagon-like peptide 1 receptor agonists have emerged as effective weight loss drugs. Nevertheless, these agents are expensive, not uniformly available, and must be used continuously.
Luisina Ongaro, Daniel Jay Bernard
openaire   +2 more sources

A new approach to an old disease: Ageing, arrhythmogenic substrate and the role of risk‐factor modification in atrial fibrillation

Experimental Physiology, EarlyView.
Abstract Atrial fibrillation (AF) prevalence rises sharply with age due to two independent mechanisms. Ageing produces irreversible arrhythmogenic substrate changes through progressive fibrosis, cellular senescence and mitochondrial dysfunction, while modifiable risk factors such as obesity, hypertension, sleep apnoea, diabetes and alcohol use promote ...
Udit Thakur, Jonathan M. Kalman
wiley   +1 more source

Putting the brakes on muscle growth: Myostatin as regulator of disuse atrophy

Experimental Physiology, EarlyView.
Abstract Skeletal muscle is a highly plastic tissue that rapidly adapts to changes in mechanical loading and metabolic activity. Periods of inactivity, including bed rest, limb immobilization or microgravity, induce a pronounced loss of muscle mass and function.
Derk H. C. Nieuwenhuijsen, Moritz Eggelbusch, Rob C. I. Wüst   +2 more
wiley   +1 more source

Activin inhibits telomerase activity in cancer

, 2009
Activin is a pleiotropic cytokine with broad tissue distributions. Recent studies demonstrate that activin-A inhibits cancer cell proliferation with unknown mechanisms.
Charley Mackenzie-Kludas (4383187), Craig Nicholls (20016081), Fang-Xu Jiang (20016084), Indzi Katik (20016078), Shufeng Zhou (398572)   +4 more
core  

Second trimester levels of maternal serum total total activin A and placental inhibin/activin a and ßA subunit messenger ribonucleic acids in Down syndrome pregnancy

, 1998
Objectives: Previous data have shown that inhibin A (alpha/betaA) is increased about twofold in maternal serum samples from Down syndrome pregnancy. Our objectives were to determine whether activin A (betaA/betaA) was similarly increased in maternal ...
FLORIO, P., LUISI, S., MAZZA, V., CANICK, J. A., PETRAGLIA, F., LAMBERT-MESSERLIAN, G. M., Mazza, Vincenzo, Petraglia, Felice   +7 more
core   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

The systemic activin response to pancreatic cancer: Implications for effective cancer cachexia therapy

, 2018
Pancreatic ductal adenocarcinoma (PDAC) is a particularly lethal malignancy with high rates of cachexia. Serum activin correlates with PDAC cachexia and mortality, while activin administration causes cachexia in mice.
Jianguo Liu, Leonidas G. Koniaris, Guanglong Jiang, Marion Couch, George E. Sandusky, Christophe Poirier, Yanlin Jiang, Xiaoling Zhong, Marianne Pons, Yunlong Liu, Teresa A. Zimmers   +10 more
core   +1 more source

Activin and Hepatocyte Growth Factor Promotes Colorectal Cancer Stemness and Metastasis through FOXM1/SOX2/CXCR4 Signaling

Gut and Liver
Background/Aims: Cancer stem cells (CSCs) are believed to drive tumor development and metastasis. Activin and hepatocyte growth factor (HGF) are important cytokines with the ability to induce cancer stemness.
Hong Peng, Ting Ye, Lei Deng, Xiaofang Yang, Qingling Li, Jin Tong, Jinjun Guo   +6 more
doaj   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Activin A does not alter striatal dopamine levels following MPTP.

, 2017
HPLC-ECD quantification of catecholamine levels revealed that activin A does not alter striatal DA (A), DOPAC (B), or HVA (C) levels following MPTP administration.
Peggy Rentsch (728462), Maximilian Bamberger (3697693), Kong M. Li (307287), Sandy Stayte (728461), Bryce Vissel (240839), Anna R. Tröscher (3697690)   +5 more
core   +1 more source