Results 191 to 200 of about 23,920,837 (347)

p21 in cancer: intricate networks and multiple activities

Nature Reviews. Cancer, 2009
T. Abbas, Anindya Dutta
semanticscholar   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Soil Composition [PDF]

Soil is essential for life on Earth. It is needed for food, air, clothing and so much more. Discussion topics include the terms 'soil', 'dirt', and 'sediment', factors affecting the formation of soils, soil horizons, and the twelve orders of soils.
Chris Fox, John Pratte
core  

What does a good day look like?: An interpretable machine learning approach to the American Time Use Survey. [PDF]

PNAS Nexus
Folk D, Henninger M, Dunn E.
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Population: Basic Statistics [PDF]

This lesson reinforces the idea that Earth's population, including the population of the United States, is gowing at a dramatic rate. It discusses some of the basics of demography, the study of population and its changes, and introduces key terms used to
John Pratte, Ken Rhinehart
core  

Lived Experiences of Returning to Participation After Mild Stroke: A Phenomenological Study in Spain. [PDF]

Health Expect
de Diego-Alonso C, Buesa Estéllez A, Güeita-Rodriguez J, Bellosta-López P, Roldán-Pérez P.   +4 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Relationships Between Frequency of Attendance, Engagement and Independence in Everyday Activities Among Children and Youth With Intellectual and Other Developmental Disabilities: The Association With Comprehension Difficulties. [PDF]

J Appl Res Intellect Disabil
Axelsson AK, Ivarsson M, Ullenhag A.
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source