Results 101 to 110 of about 18,252,443 (306)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Quantitative structure-activity relationship for antimalarial activity of artemisinin [PDF]
, 2010 The increase in resistance to older drugs and the emergence of new types of infection have created an urgent need for discovery and development of new compounds with antimalarial activity.
Hasan, Mohamed Noor +1 more
core
Five ways to model active processes in elastic solids: Active forces, active stresses, active strains, active fibers, and active metrics [PDF]
Mechanics Research Communications, 2018 An important contribution of Gerard Maugin was his study of anelasticity. It is well appreciated that in biological systems, anelasticity manifests itself through growth and remodeling and Maugin and his collaborators have helped build a general theory suitable to model such fundamental processes.
openaire +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Wandering Poles in the Last 2000 Years [PDF]
In this activity students will plot the location of the north magnetic pole for the last 2000 years on a map and explore how it has changed location.
core
Shaping Social Activity by Incentivizing Users [PDF]
, 2014 Events in an online social network can be categorized roughly into endogenous events, where users just respond to the actions of their neighbors within the network, or exogenous events, where users take actions due to drives external to the network.
Du, Nan +5 more
core +3 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Sending Data from a Satellite Back to Ground [PDF]
In this activity, students will learn how a satellite communicates information to the earth. They will discover that satellites use a transmitter and reciever system to send information and that the information must be transmitted correctly, recieved ...
core
L’awareness à l’épreuve des activités dans les centres de coordination
Activités, 2005 In Situated Action models, issued from ethno-methodology, the awareness state present in Coordination Centers constitutes the foundation necessary for coordinating operators’ activities, which in turn, will assure a robust work collective.
Michèle Grosjean
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source