Results 221 to 230 of about 8,083,437 (318)

Benzimidazole-Quinoline Hybrids: Synthesis and Antimicrobial Properties. [PDF]

Pharmaceuticals (Basel)
Marinescu M.
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Pinopsin Regulates Melatonin Production and Daily Locomotor Activity: Functional Insights From Gene-Edited Xenopus Tadpoles. [PDF]

J Pineal Res
Heshami N, Romero RD, de Souza FSJ, Bertolesi GE, McFarlane S.   +4 more
europepmc   +1 more source

IN VITRO ANTIOXIDANT ACTIVITIES, TOTAL FLAVONOID, PHENOLIC AND CAROTENOID CONTENT FROM VARIOUS EXTRACTS OF FOUR SPECIES ASTERACEAE HERB

, 2015
Irda Fidrianny Ibrahim, Evelyne Nadia, Komar Ruslan W   +2 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Steroidal Compounds at the Crossroads of Inflammation and Cancer: Implications for Drug Discovery and Therapy. [PDF]

Biomedicines
Dembitsky VM, Terent'ev AO.
europepmc   +1 more source

Wearable Sensors to Monitor Physical Activity in Heart Failure Clinical Trials: State-of-the-Art Review [PDF]

Rubén Buendía, Martin Karpefors, Folke Folkvaljon, ROBERT HUNTER, Henrik Sillén, Long Luu, Kieran F. Docherty, Martín Cowie   +7 more
openalex   +1 more source