Results 221 to 230 of about 6,345,889 (290)

Isocyanate‐Modified Melatplatin(IV) Enhances Antitumor Efficacy via TCF4/COL6A3‐Mediated Extracellular Matrix Remodeling and cGAS‐STING Pathway Activation in Bladder Cancer

Advanced Science, EarlyView.
A series of melatonin‐conjugated platinum(IV) prodrugs was functionalized with isocyanate chains (compounds 5‒12). MP‐12C (compound 11) was identified as the lead candidate, with optimal potency and safety. MP‐12C exhibited greater efficacy than cisplatin by increasing intracellular uptake, reshaping the extracellular matrix, activating the cGAS‐STING ...
Linhui Wang, Xiaomeng Liu, Tao Zhu, Zirun Su, Ruiping Liu, Zhe Li, Kaixuan Du, Kaipeng Jia, Chong Fu, Yuda Lin, Zihan Xue, Zhe Zhang, Chong Shen, Yunkai Qie, Zhouliang Wu, Zhiheng Liu, Kangkang Liu, Jingyuan Xu, Hailong Hu   +18 more
wiley   +1 more source

Evaluation of Overwintering Performance of Threeline Grunt (<i>Parapristipoma trilineatum</i>) in Sea Cages Along the Southern Coast of Korea. [PDF]

Animals (Basel)
Baek SI, Ryu YW, Im KH, Kim KW, Park JW.
europepmc   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Novel bicolumnar fixation with primary cup implantation for pelvic discontinuity in revision hip arthroplasty: a comparative clinical study. [PDF]

Arch Orthop Trauma Surg
Abul MS, Ağır M, Yılmaz H, Hekim Ö, Sevim ÖF, Tuncay İ.   +5 more
europepmc   +1 more source

Developmental Environmental Chronotoxicity by Polystyrene Nanoplastics Exacerbates High‐Fat Diet‐Induced Pediatric MAFLD Through Circadian Disruption and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Polystyrene nanoplastics exacerbate high‐fat diet‐induced metabolic dysfunction in an age‐dependent manner. Juvenile mice exhibit greater susceptibility, characterized by circadian disruption, impaired mitochondrial function, reduced energy metabolism, and enhanced hepatic lipid accumulation.
Peihao Xu, Shuting Huang, Leilei Zhu, Junyi Huang, Kewei Li, Guangming Li, Jiannong Wu, Mingyuan Zhou, Fangmei Zhou, Zhishan Ding, Yingzhi Shen   +10 more
wiley   +1 more source

Soda-baited RNAi yeast insecticides as effective Attractive Targeted Sugar Baits (ATSBs) for mosquito control. [PDF]

PLoS Negl Trop Dis
Stewart ATM, Hamid-Adiamoh M, Njoroge TM, Sun L, Winter-Reece N, Shui Feng R, Singh S, James LD, Sofhauser B, Dille C, Mohammed A, Severson DW, Duman-Scheel M.   +12 more
europepmc   +1 more source

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source

Shotgun metagenomic profiling of the fecal microbiome in Lamp2 knockout mice reveals limited genotype-associated differences under standard housing. [PDF]

PLoS One
Emfietzoglou M, Bantounou MA, Osmani S, Narimatsu T, Baroutis KG, Varsamidaki A, Skondra D, Papaconstantinou D, Theodossiadis P, Chatziralli I, Miller JW, Vavvas DG.   +11 more
europepmc   +1 more source

Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D‐Serine Signaling

Advanced Science, EarlyView.
Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han, Minwoo Wendy Jang, Taeyoung Park, Ki Jung Kim, Victor James Drew, Sunpil Kim, Tai Young Kim, Mingu Gordon Park, Myeongju Kim, Seung Won Chung, Minah Suh, C. Justin Lee   +11 more
wiley   +1 more source

fruitless is essential for male Aedes aegypti mosquito attraction to female flight sounds. [PDF]

PLoS Biol
Loh YM, Thornton AJ, Loh W, Lee TT, Chen WT, Xu YYJ, Yap JX, Tsuchiya Y, Eberl DF, Su MP, Kamikouchi A.   +10 more
europepmc   +1 more source