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Bioorthogonal Enzymatic Activation of Caged Compounds
Angewandte Chemie International Edition, 2015AbstractEngineered cytochrome P450 monooxygenase variants are reported as highly active and selective catalysts for the bioorthogonal uncaging of propargylic and benzylic ether protected substrates, including uncaging in living E. coli. observed selectivity is supported by induced‐fit docking and molecular dynamics simulations.
Ritter, C. +9 more
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Image Segmentation With Cage Active Contours
IEEE Transactions on Image Processing, 2015In this paper, we present a framework for image segmentation based on parametrized active contours. The evolving contour is parametrized according to a reduced set of control points that form a closed polygon and have a clear visual interpretation. The parametrization, called mean value coordinates, stems from the techniques used in computer graphics ...
Lluís Garrido +2 more
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Cage activity in cottontail rabbits
Psychonomic Science, 1970Cage activity of two cottontail rabbits was measured twice daily (morning and night) under six levels of ambient illumination (dark, less than 1.0, 2.5, 5.0, 25.0, and 50.0 fc). Analysis of variance indicated that the Ss were significantly more active at night than in the morning under all levels of illumination.
Donna M. Cone, A. L. Cone
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Microprocessor based activity cage
Proceedings of the First Regional Conference, IEEE Engineering in Medicine and Biology Society and 14th Conference of the Biomedical Engineering Society of India. An International Meet, 2002Activity cages have wide applications in pharmacology, toxicology, psychology, neurology, physiology and entomology. To monitor and to provide information about animal activity continuously for a given period of time, activity cages are used. The activity of the drug/toxin injected animal will have three types of movements, namely, ambulatory ...
M. Nagesh, M. Venkateswara Rao
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Quantitative Packaging of Active Enzymes into a Protein Cage
Angewandte Chemie International Edition, 2015AbstractGenetic fusion of cargo proteins to a positively supercharged variant of green fluorescent protein enables their quantitative encapsulation by engineered lumazine synthase capsids possessing a negatively charged lumenal surface. This simple tagging system provides a robust and versatile means of creating hierarchically ordered protein ...
Yusuke Azuma +3 more
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Redox Active Cage for the Electrochemical Sensing of Anions
Inorganic Chemistry, 2008The tripodal system [1]3+ forms a 1:1 complex with CoII in which the metal is octahedrally coordinated by three bpy fragments. The [CoII(1)]5+ complex provides a cavity suitable for solvent or anion inclusion. X-ray diffraction studies on the crystalline complex salt of formula [CoII(1)...H2O]Cl(PF6)(4).2MeCN have shown that a water molecule is ...
Amendola, Valeria +6 more
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Biologic activity of cyclic and caged phosphates: a review
Journal of Applied Toxicology, 2016AbstractThe recognition in the early 1960s by Morifusa Eto that tri‐o‐cresyl phosphate (TOCP) is hydroxylated by the cytochrome P450 system to an intermediate that spontaneously cyclizes to a neurotoxic phosphate (saligenin phosphate ester) ignited the interest in this group of compounds.
Dietrich E, Lorke +2 more
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Nutating Annular Cage for Measuring Motor Activity
Science, 1963The construction of an activity-measuring device that utilizes a nutating annular animal enclosure is described. The instrument converts motor activity to numerical scores. With mice, the logarithms of these scores assume a normal distribution. A second test occurring 1 day, week, or month after the first fails to exhibit any habituation of the animals.
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An activity cage and recorder for domestic fowl
Animal Behaviour, 1959Abstract An activity cage and recorder were constructed for use with domestic fowl and small animals. The cage consisted of a square cage mounted on a centre post, pins and microswitches. Two magnetic counters, activated by the micro-switches, served as recorders.
S.C. Ratner, R.K. Ringer
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Circadian Analysis of Rodent Locomotor Activity in Home Cages
2022Rhythmic locomotor activity is a commonly used readout of general circadian function in animals. For instance, measuring the activity of rodents in their home cages can provide information about circadian phase and period in response to genetic, pharmacological, and environmental manipulations.
Paul, Petrus, Paolo, Sassone-Corsi
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