Results 91 to 100 of about 3,944,530 (288)
Reversible adsorption on a random site surface
, 2006 We examine the reversible adsorption of hard spheres on a random site surface in which the adsorption sites are uniformly and randomly distributed on a plane. Each site can be occupied by one solute provided that the nearest occupied site is at least one
Adamczyk +25 more
core +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Shocking the Crowd: The Effect of Censorship Shocks on Chinese Wikipedia
, 2017 Collaborative crowdsourcing has become a popular approach to organizing work across the globe. Being global also means being vulnerable to shocks -- unforeseen events that disrupt crowds -- that originate from any country.
Budak, Ceren +4 more
core +3 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Where Theory meets Practice: A Case for an Activity Theory based Methodology to guide Computer System Design [PDF]
, 2001 Computer system developers are increasingly being challenged to develop tools that are not only usable, but more importantly useful in the sense of assisting the user to achieve desired goals. This requirement has highlighted the importance of accounting
Mwanza, Daisy
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Criminologie, 2019 Les activités criminelles font partie de la catégorie des activités de la vie sociale sur lesquelles pèse une certaine stigmatisation. Des recherches en criminologie ont cependant démontré que les personnes qui exercent ces activités en retirent des ...
Marie-Michelle Pariseau, Eddy Supeno
doaj +1 more source
How strong are correlations in strongly recurrent neuronal networks?
, 2018 Cross-correlations in the activity in neural networks are commonly used to characterize their dynamical states and their anatomical and functional organizations.
Darshan, Ran +2 more
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source