Results 71 to 80 of about 3,944,530 (288)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
The Contribution of a Community Event to Expert Work: An Activity Theoretical Perspective
Outlines, 2004 Becoming an expert in any knowledge domain takes time and a great deal of learning, both theoretical and experiential. The individual’s knowledge is often supplemented through knowledge exchanges with other experts.
Alanah Kazlauskas, Kathryn Crawford
doaj
Differential-activity driven instabilities in biphasic active matter [PDF]
, 2017 Active stresses can cause instabilities in contractile gels and living tissues. Here we describe a generic hydrodynamic theory that treats these systems as a mixture of two phases of varying activity and different mechanical properties.
Mahadevan, L. +2 more
core +3 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Outlines, 2008 This paper examines how a classroom culture developsadvanced strategies and procedures for handling complexdigital tools. We report from a vocational Mediaand Communication course at an Upper SecondarySchool in Oslo, Norway.
Thomas de Lange, Andreas Lund
doaj
Agency and the physics of numbers
, 2018 Analogous to G\"odel's incompleteness theorems is a theorem in physics to the effect that the set of explanations of given evidence is uncountably infinite.
Madjid, F. Hadi, Myers, John M.
core +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Outlines, 2004 Workplace learning and competence development in work are frequently used concepts. A wide spread notion is that societal, institutional, and organizational changes require the development of knowledge, methods and strategies for learning at workplaces ...
Kristina Westerberg
doaj
How to find and understand development problems and learning challenges in organic vegetable farming? [PDF]
, 2004 Laura Seppänen's doctoral dissertation in agroecology, using an approach derived from cultural historical activity theory, examines the developmental problems and learning challenges in organic vegetable ...
Seppänen, Laura
core