Results 61 to 70 of about 3,944,530 (288)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Theory of active chromatin remodeling [PDF]

Physical Review Letters, 2019
Nucleosome positioning controls the accessible regions of chromatin and plays essential roles in DNA-templated processes. ATP driven remodeling enzymes are known to be crucial for its establishment in vivo, but their non-equilibrium nature has hindered the development of a unified theoretical framework for nucleosome positioning.
Jiang, Zhongling, Zhang, Bin
openaire   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Theory of population coupling and applications to describe high order correlations in large populations of interacting neurons

, 2017
To understand the collective spiking activity in neuronal populations, it is essential to reveal basic circuit variables responsible for these emergent functional states.
Huang, Haiping
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Identifying health and wellbeing related information management activities and needs in families with young children

Finnish Journal of eHealth and eWelfare, 2012
Understanding how families manage health and wellbeing related information in their everyday lives is important in the user-centric design of information and communication technology (ICT) supported services.
Marilla Palmén, Mikko Korpela, Kaija Saranto   +2 more
doaj  

Conceptions Connected to Early Academic Studies in Computer Science: Focusing on Students, Lecturers, and Parents

Education Sciences
The goal of this study was to identify conceptions towards early academic studies in computer science. We focus on a program which offers high school students the unique opportunity to earn a B.Sc.
Lior Miller-Markovitz, Gad M. Landau, Daphna Haran, Roza Leikin   +3 more
doaj   +1 more source

Magnetic Helicity Evolution During the Solar Activity Cycle: Observations and Dynamo Theory

, 2003
We study a simple model for the solar dynamo in the framework of the Parker migratory dynamo, with a nonlinear dynamo saturation mechanism based on magnetic helicity conservation arguments.
Abramenko, Abramenko, Baliunas, Bao, Berger, Blackman, Blackman, Brandenburg, Brandenburg, Brandenburg, Brooke, Bruevich, Chae, Covas, D. Moss, D. Sokoloff, Dikpati, Field, Frisch, Galitski, H. Zhang, Hoyt, I. Rogachevskii, Iroshnikov, K. Kuzanyan, Kleeorin, Kleeorin, Kleeorin, Kleeorin, Kleeorin, Kleeorin, Kleeorin, Kuzanyan, Longcope, N. Kleeorin, Parker, Pevtsov, Pevtsov, Pevtsov, Rogachevskii, Rogachevskii, Rust, Rüdiger, Seehafer, Sofia, Sokoloff, Spruit, Subramanian, Tavakol, Wang, Woltjer, Zhang, Zhang, Zhang, Zhang, Zhang   +55 more
core   +1 more source

Cognitive Science and Psychology [PDF]

, 1994
The protocol algorithm abstracted from a human cognizer's own narrative in the course of doing a cognitive task is an explanation of the corresponding mental activity in Pylyshyn's (1984) virtual machine model of mind.
Chow, Dr Siu L.
core   +1 more source