Results 81 to 90 of about 3,944,530 (288)

Decoding neural responses to temporal cues for sound localization [PDF]

, 2013
The activity of sensory neural populations carries information about the environment. This may be extracted from neural activity using different strategies.
Aitkin, Ashida, Attwell, Brette, Briley, Carandini, Carlile, Casseday, Coles, Couchman, Couchman, Day, Dayan, Devore, Fischer, Fischer, Fitzpatrick, Fontaine, Furukawa, Glasberg, Goodman, Goodman, Gourévitch, Grothe, Hancock, Harper, Heffner, Heffner, Heffner, Heffner, Jeffress, Jenkins, Joris, Knudsen, Konishi, Kuenzel, Kuhn, Kuwada, Köppl, Lee, Lesica, Litovsky, Lüling, Maki, Makous, Malhotra, McAlpine, Miller, Moiseff, Moore, Pedregosa, Populin, Shera, Slaney, Sparks, Stecker, Sterbing, Stern, Takahashi, Thompson, Tollin, Tollin, Tollin, Wagner, Wakeford, Wightman, Yin, Yin, Yin   +68 more
core   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Situating partnership activity, an activity theory inspired analysis of school to school inquiry networks

Cogent Education, 2019
The issue of how schools work in partnership with each other and with other organisations has always been of interest to school leaders, policymakers, and practitioners.
Andrew Townsend
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

New academics’ experiences of induction to teaching: an Activity Theory approach [PDF]

, 2019
In this article we present findings of a research project investigating the experiences of new academics in the process of becoming effective teachers, using an Activity Theory framework (Engestrom, 2001 ).
Allin, Linda, Anderson, Emma, Black, Kate, Hooper, Helen, Mathieson, Susan, Mcinnes, Lynn, Orme, Elizabeth, Penlington, Roger   +7 more
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Organizational Boundary Crossing Actions and Optimization Strategies in the Implementation of the "National Excellent Primary and Secondary School Teacher Training Program ": From the Perspective of Activity Theory

Jiaoshi jiaoyu xuebao
In July 2023, China issued the Opinions of the Ministry of Education on Implementing the National Excellent Primary and Secondary School Teacher Training Plan, which requires the implementation of the "National Excellent Primary and Secondary School ...
CAO Taisheng, ZHAI Chenqi
doaj   +1 more source

Metastability, Criticality and Phase Transitions in brain and its Models [PDF]

, 2006
This essay extends the previously deposited paper "Oscillations, Metastability and Phase Transitions" to incorporate the theory of Self-organizing Criticality.
Werner, MD Gerhard
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source