Results 51 to 60 of about 603,389 (218)

The Contribution of a Community Event to Expert Work: An Activity Theoretical Perspective

open access: yesOutlines, 2004
Becoming an expert in any knowledge domain takes time and a great deal of learning, both theoretical and experiential.  The individual’s knowledge is often supplemented through knowledge exchanges with other experts.
Alanah Kazlauskas, Kathryn Crawford
doaj  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Digital Tools and Instructional Rules: A study of how digital technologies become rooted in classroom procedures

open access: yesOutlines, 2008
This paper examines how a classroom culture developsadvanced strategies and procedures for handling complexdigital tools. We report from a vocational Mediaand Communication course at an Upper SecondarySchool in Oslo, Norway.
Thomas de Lange, Andreas Lund
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Workplace development and learning in elder care – the importance of a fertile soil and the trouble of project implementation

open access: yesOutlines, 2004
Workplace learning and competence development in work are frequently used concepts. A wide spread notion is that societal, institutional, and organizational changes require the development of knowledge, methods and strategies for learning at workplaces ...
Kristina Westerberg
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Situating partnership activity, an activity theory inspired analysis of school to school inquiry networks

open access: yesCogent Education, 2019
The issue of how schools work in partnership with each other and with other organisations has always been of interest to school leaders, policymakers, and practitioners.
Andrew Townsend
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Organizational Boundary Crossing Actions and Optimization Strategies in the Implementation of the "National Excellent Primary and Secondary School Teacher Training Program ": From the Perspective of Activity Theory

open access: yesJiaoshi jiaoyu xuebao
In July 2023, China issued the Opinions of the Ministry of Education on Implementing the National Excellent Primary and Secondary School Teacher Training Plan, which requires the implementation of the "National Excellent Primary and Secondary School ...
CAO Taisheng, ZHAI Chenqi
doaj   +1 more source

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