Development of a feedback framework within a mentorship alliance using activity theory. [PDF]
Afr J Health Prof Educ, 2021 Mubuuke AG +6 more
europepmc +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
An activity theory approach to analysing student learning of human anatomy using a 3D-printed model and a digital resource. [PDF]
BMC Med EducLee JWY +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Correction: An activity theory approach to analysing student learning of human anatomy using a 3D-printed model and a digital resource. [PDF]
BMC Med EducLee JWY +4 more
europepmc +1 more source
The Emotions in Cultural-Historical Activity Theory: Personality, Emotion and Motivation in Social Relations and Activity. [PDF]
Integr Psychol Behav Sci, 2021 Burkitt I.
europepmc +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Addressing Teamwork Delays during Life-Saving Interventions through an Activity Theory-Informed Analysis. [PDF]
Proc ACM Hum Comput InteractZellner KA +6 more
europepmc +1 more source
Getting palliative medications right across the contexts of homes, hospitals and hospices: protocol to synthesise scoping review and ethnographic methods in an activity theory analysis. [PDF]
BMJ Open, 2022 Yardley S +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source