Results 181 to 190 of about 11,976,431 (285)

Activity Theory Applied to the Desktop Metaphor

, 2011
Although the desktop metaphor is still the de facto in desktop computing, many problems and limitations have been recognized over the years. Although there are many novel approaches that try to solve these problems and limitations, no valid alternative ...
Houben, Steven
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

An activity theory-based exploration of "Eyeland", a task-based serious game for EFL visually impaired students. [PDF]

PeerJ Comput Sci
Villalba K, Robles H, Jimeno M, Delgado-Cañas MC, Perez A, Quintero F.   +5 more
europepmc   +1 more source

Vietnamese non-English-major students' motivation to learn English: from activity theory perspective. [PDF]

Heliyon, 2021
Nguyen SV, Habók A.
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

From Learner to Provider: Navigating Role Tensions in Postgraduate Medical Training Through Activity Theory. [PDF]

Perspect Med Educ
Kwong SP, Yu SR, Liao KC, Liao SC, Hsiao CT, Chaou CH.   +5 more
europepmc   +1 more source

Development of a feedback framework within a mentorship alliance using activity theory. [PDF]

Afr J Health Prof Educ, 2021
Mubuuke AG, Munabi IG, Mbalinda SN, Kateete D, Opoka RB, Chalo RN, Kiguli S.   +6 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

An activity theory approach to analysing student learning of human anatomy using a 3D-printed model and a digital resource. [PDF]

BMC Med Educ
Lee JWY, Low LXT, Ong DW, Bello F, Soh RCC.   +4 more
europepmc   +1 more source

The Emotions in Cultural-Historical Activity Theory: Personality, Emotion and Motivation in Social Relations and Activity. [PDF]

Integr Psychol Behav Sci, 2021
Burkitt I.
europepmc   +1 more source