Results 171 to 180 of about 11,976,431 (285)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

A Study on the Methodology for Constructing Interoperability Technology Requirement System for Autonomous Transportation

open access: yesKongzhi Yu Xinxi Jishu
Current intelligent transportation systems (ITS) are gradually evolving toward autonomous transportation systems (ATS) with capabilities of self-perception, self-adaptation, self-learning, self-decision-making, self-repair, and self-evolution ...
WANG Quandong   +5 more
doaj  

IS Design as Domain Construction

open access: yes, 2004
In this paper we describe a method for IS design which focus on constructing the social reality in which the IS is used. This reality is structured as a particular form of work practice – the activity domain – which is the main construct in the Activity ...
Taxén, Lars
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

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