Results 41 to 50 of about 183,316 (279)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Using actor network theory ideas in information systems research: a case study of action research [PDF]

, 2004
Actor-Network Theory has found some favour in information systems research as a tool for interpretation and description of sociological phenomena surrounding the use of information systems.
Townson, C J W, Lewis, P J
core  

Development of a successful microfinancing system: Actor-network theory perspective

Management : Journal of Contemporary Management Issues, 2019
The article aims to answer the following research question: “How were actors mobilized to form a network for promoting microfinancing system in a transforming country?”.
Halina Waniak-Michalak, Jan Michalak
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

SME leaders’ learning in networked learning : an actor-network theory and communities of practice theory informed analysis [PDF]

, 2011
This thesis brings a Communities of Practice perspective together with Actor-network theory to provide a rich understanding of the social learning processes of SME leaders within a networked learning programme.
Hodgson, Vivien, Rose, Mary, Smith, Sue, Smith, Susan M   +3 more
core  

Approaching Participatory documentary networks and networking: From Actor Network Theory to Interventionist Networking Methodology

Interfaces Numériques, 2019
This contribution conceives of interactive documentaries as relational configurations – as a nexus of discourses and practices. By building theory from practice (i.e. two case studies of interactive documentaries), the axioms of Actor Network Theory will
Anna Wiehl
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The Problem of Relevance in Post-Actor-Network Theory

Социология власти
The article is devoted to the problem of relevance in post-actor network theory. In the context of the turn to the material in sociological theory, one of the key tasks is to determine the relevance of non-humans in social interactions or in broader ...
M. D. Malkov
doaj   +1 more source