Results 71 to 80 of about 359,514 (275)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The Campaign: a case study in identity construction through performance [PDF]

, 2009
This article undertakes a detailed case study of The Campaign, a teaching and learning innovation in media and communications that uses an online educational role-play.
Riddle, Matthew
core   +3 more sources

Diásporas y transiciones en la Teoría del Actor-Red Diasporas and transitions in Actor-Network Theory

Athenea Digital, 2011
Este texto es una presentación del monográfico Diásporas y transiciones en la teoría del actor-red. Sus páginas presentan las principales características de esta teoría, una ...
Blanca Callén, Miquel Domènech, Daniel López, Israel Rodríguez Giralt, Tomás Sánchez-Criado, Francisco Javier Tirado Serrano   +5 more
doaj  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Toward and Analytical and Methodological Understanding of Actor Network Theory [PDF]

, 2015
Actor-network theory (ANT) is well developed within social studies of science and technology. The last two decades have seen an increasing awareness and interest in ANT within the social sciences and it has increasingly been invoked to theorise the role ...
Jackson, Sharon
core   +1 more source

Michael Porter's Cluster Theory as a local and regional development tool – the rise and fall of cluster policy in the UK [PDF]

, 2013
There has been much written on industrial agglomeration, but it is Michael Porter’s cluster theory, above all others, which has come to dominate local and regional economic development policy. His work has been adopted by the OECD, EU, national and local
Swords, Jon
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The role of actor-networks in the diffusion of management accounting innovations: a comparative study of budgetary control, GP method and Activity-Based Costing in France [PDF]

This research is concerned with the diffusion of management accounting innovations viewed as a process of actor-network building and translation. The aim is to better understand the nature of accounting change.
Nicolas Berland, Simon Alcouffe, Yves Levant   +2 more
core  

Epidemic space [PDF]

, 2005
The aim of this article is to highlight the importance of 'spatiality' in understanding the materialization of risk society and cultivation of risk sensibilities.
Anderson M, Beck U, Beck U, Bouter, Brewster DD, Cann AJ, Cannon G, Christie AB, Derrida J, Douglas M, Evans AS, Evans AS, Ewald P, Ewald P, Eyles J, Foucault M, Garret L, Gisselchrist D, Gisselchrist D, Grist NR, Haraway D, Heidegger M, Holland J, Johnson K, Joost van Loon, Latour B, Latour B, Latour B, Latour B, Lefebvre H, Levine A, Lilienfeld DA, Lupton D, Margulis L, McCormick JB, McNeill WH, Old RW, Peters CJ, Preston R, Rothschild H, Ryan F, Ryan F, Sapp J, Shields R, Shope RE, Sontag S, Treichler P, van Loon J, van Loon J, van Loon J, Wills C   +50 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source