Results 131 to 140 of about 5,293,771 (310)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Положение Молдавской Церкви во время русско-турецкой войны 1768–1774 гг.

Revista de Etnologie şi Culturologie, 2017
This article examines the reasons for the conversion of Moldovan boyars and church leaders to Russia during the Russian-Turkish war of 1786–1774. They asked the Russian authorities to grant them citizenship, motives for which Russia wanted to include the
Alexandr Ponomariov
doaj  

ACTS propagation terminal update [PDF]

The activities at Virginia Polytechnic Institute and State University in preparation for the February 1993 launch of ACTS are summarized. ACTS propagation terminals (APT) are being constructed to receive the 20 and 27.5 GHz ACTS beacon signals.
Pratt, Tim, Stutzman, Warren L.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Activist Citizenship, Film and Peacebuilding: Acts and Transformative Practices

Journal for Religion, Film and Media, 2016
In this article I explore film as a socio-political and artistic-transformative cultural practice through which acts and activism are performed.
Milja Radovic
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Corruption in the Local Government System of the Russian State (According to Investigative Cases of the 1590–1630s)

Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения
Introduction. The purpose of the article is to study how corruption was understood in the Moscow state and how the fight against it was carried out in the system of local government to show the vector of institutional shift in the Russian state of ...
Vladimir Arakcheev
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Paul and the Asiarchs. Acts 19:31 in the Controversy of Historians

Gephyra, 2005
Paul and the Asiarchs. Acts 19:31 in the Controversy of HistoriansIn the discussion about the Asiarchs' office in cities of Asia Minor during the imperial age, Acts 19:31 has rarely been employed as a source text in its own right.
Stephan Witetschek
doaj