Results 111 to 120 of about 3,464 (299)
IPERS Employer Bulletin 2011-1, November 22, 2011 [PDF]
, 2011 IPERS’ actuary completed the annual valuation and certified the contribution rates for fiscal year 2012 for sheriffs, deputy sheriffs, and members in other protection occupations.
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Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
National population projections 1992-based
, 1995 Prepared by the Government Actuary in consultation with the Registars General.
Office of Population Censuses and Surveys, London (United Kingdom). Social Survey Div
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Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
BMC GeriatricsBackground Non-communicable diseases (NCDs) account for an estimated 80% of the healthcare burden among older adults globally. Aerobic physical activity (PA) contributes to functional mobility, increased bone and muscle strength, prevention of illness ...
Andrea M. Madden +10 more
doaj +1 more source
The famous italian actuary gaetano balducci and some calculations based on his offered assumption. [PDF]
Balducci assumption is widely spread in the actuarial science literature, however, it lacks sources that analyse the reasoning behind the creation of that assumption, as well as the Italian actuary Gaetano Balducci himself.
Matulevičiūtė, Eglė,
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A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
They Learned the Course! Why Then Do They Come to Tutorials? [PDF]
Journal of Systemics, Cybernetics and InformaticsThe paper explores after-course preparation for certification exams. The question addressed is, "What are the broad themes for seeking tutorial help after course completion? What types of problems are typical during tutorial help?
Russell Jay Hendel
doaj
La loi sur l’abolition de la retraite obligatoire
, 1982 Should retirement be compulsory from a certain age? The question has now been answered in Quebec by Bill 15, which took effect on April 1st 1982. Mr.
Garcia, Claude
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