Results 111 to 120 of about 3,093 (299)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
They Learned the Course! Why Then Do They Come to Tutorials? [PDF]
Journal of Systemics, Cybernetics and InformaticsThe paper explores after-course preparation for certification exams. The question addressed is, "What are the broad themes for seeking tutorial help after course completion? What types of problems are typical during tutorial help?
Russell Jay Hendel
doaj
The challenge of healthcare big data to China's commercial health insurance industry: evaluation and recommendations. [PDF]
BMC Health Serv Res, 2022 Wu J +4 more
europepmc +1 more source
Future Productivity Growth in Canada and Implications for the Canada Pension Plan [PDF]
This is organized into three main parts. The first section provides a perspective on future productivity growth in Canada. It discusses key productivity concepts, looks at current productivity trends, examines the forces affecting future productivity ...
Andrew Sharpe
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
The famous italian actuary gaetano balducci and some calculations based on his offered assumption. [PDF]
Balducci assumption is widely spread in the actuarial science literature, however, it lacks sources that analyse the reasoning behind the creation of that assumption, as well as the Italian actuary Gaetano Balducci himself.
Matulevičiūtė, Eglė,
core
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Limited liabilities option valuation model
Acta Economica, 2012 Limited liabilities are ofen viewed as the valuable protection of personal property to the investors in equity instruments. Tere are several approaches for valuing limited liabilities.
Силвије Орсаг
doaj
IEEE AccessStochastic optimal control problems are commonly formulated as optimization problems constrained by stochastic dynamical systems, whose value functions satisfy Hamilton–Jacobi–Bellman (HJB) equations.
Alvian Alif Hidayatullah +7 more
doaj +1 more source