Results 111 to 120 of about 20,866 (302)
The challenge of healthcare big data to China's commercial health insurance industry: evaluation and recommendations. [PDF]
BMC Health Serv Res, 2022 Wu J +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
IEEE AccessStochastic optimal control problems are commonly formulated as optimization problems constrained by stochastic dynamical systems, whose value functions satisfy Hamilton–Jacobi–Bellman (HJB) equations.
Alvian Alif Hidayatullah +7 more
doaj +1 more source
Pension choices and job mobility in the UK. [PDF]
Using data from the British Household Panel Survey we analyze the impact of second tier pension schemes on voluntary job mobility within a discrete time hazard rate modelling framework.
Andrietti, Vincenzo
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Limited liabilities option valuation model
Acta Economica, 2012 Limited liabilities are ofen viewed as the valuable protection of personal property to the investors in equity instruments. Tere are several approaches for valuing limited liabilities.
Силвије Орсаг
doaj
Who Pays if We Raise the Social Security Payroll Tax Cap? [PDF]
, 2017 Most Americans know that their earnings are subject to the Social Security payroll tax. Not as many are aware that the amount of earnings subject to the tax, while subject to change, is capped at the same level for everyone, regardless of total earnings.
Alan Barber, Cherrie Bucknor
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source