Results 121 to 130 of about 3,464 (299)
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
The challenge of healthcare big data to China's commercial health insurance industry: evaluation and recommendations. [PDF]
BMC Health Serv Res, 2022 Wu J +4 more
europepmc +1 more source
An analysis of actuarial science in literature
, 2019 Actuarial Science is a growing field in the larger world of mathematics, insurance, and risk management. However, despite this growth, compared to other similar fields it is not as well known nor is it a well featured profession in the world of novels ...
Clark, Emily
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DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
[Photograph 2012.201.B0328.0283]
, 1953 Photograph used for a story in the Daily Oklahoman newspaper. Caption: "Shakeup of the state insurance board took another top hand off the job Tuesday when actuary Finis LaFon was replaced. Mott M.
Lucas, Jim
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IPERS Employer Bulletin 2010-2, November 15, 2010 [PDF]
, 2010 IPERS’ actuary completed the annual valuation and certified the contribution rates for fiscal year 2012 for sheriffs, deputy sheriffs, and members in other protection occupations.
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Loss Reserve Estimating and Actuaries Switching in the U.S. Property Casualty Insurance Industry
, 2015 This paper aims to examine the U.S. property casualty insurer’s organizational structure, corporate governance and loss reserve estimating in relation to actuaries switching.
何佳玲
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source