Results 141 to 150 of about 20,866 (302)

Actuarial values [PDF]

, 1998
This paper seeks to identify the characteristic values implicit in contemporary actuarial\ud thought and practice. ‘Values’ is used here to mean fundamental concepts which we\ud use, largely intuitively, to guide our patterns of thought and behaviour. We consider to\ud what extent these values are characteristic simply because actuarial work attracts ...
openaire  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Options to Extend Medicare's Trust Fund: Lessons From Japan's Statutory Health Insurance. [PDF]

Inquiry, 2022
Maeda JLK.
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

How can actuarial science contribute to the field of health technology assessment? An interdisciplinary perspective. [PDF]

Int J Technol Assess Health Care
Espinosa O, Drummond M, Russo E, Williams D, Wix D.   +4 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Exploring and enhancing community awareness on antimicrobial resistance: perspectives from world antimicrobial resistance awareness week celebration in Ghana. [PDF]

BMC Public Health
Loglo AD, Nkrumah-Appau M, Deke J, Asiamah CK, Antwi PB, Newton S, Kotochi S, Nyame MK, Oppong M, Adu CAT, Dorkenoo RM, Sogbo V, Boadi AO, Ayinlooya NEA, Manu S, Amoah B, Ankomah J, Quartey MK, Bansah SE, Essel W, May J, Dekker D, Berg S, Khan N, Akenten CW.   +24 more
europepmc   +1 more source

Physical work exposure matrix for use in the UK Biobank. [PDF]

Occup Med (Lond), 2022
Yanik EL, Stevens MJ, Harris EC, Walker-Bone KE, Dale AM, Ma Y, Colditz GA, Evanoff BA.   +7 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Extreme Temperatures, Hospital Utilization and Public Health Insurance Spending. [PDF]

Int J Public Health
Kim Y, Miao Q, Zhu L.
europepmc   +1 more source