Results 51 to 60 of about 3,093 (299)

Nonparametric Predictive Inference for Discrete Lifetime Data

open access: yesMathematics
This paper presents nonparametric predictive inference for discrete lifetime data. While lifetimes are mostly treated as continuous random variables in statistics, there are scenarios where time observations are recorded as discrete values, for example ...
Frank P. A. Coolen   +2 more
doaj   +1 more source

Del "scriptor" al "publicus notarius" : los escribanos de Madrid en el siglo XIII

open access: yesEspacio, Tiempo y Forma. Serie III, Historia Medieval, 2003
Estudio diplomático y jurídicoinstitucional de las escribanías de Madrid en el siglo XIII. Se analiza su evolución desde los primeros "Scriptores» prenotariales conocidos, clérigos y laicos de libre profesión, documentados hasta 1260, hasta la ...
María Teresa Carrasco Lazareno
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Actual replacement rates for retiring workers / [PDF]

open access: yes, 1977
"October 1977.""Office of the Actuary."Caption title.Mode of access ...
United States. Social Security Administration. Office of the Actuary.   +1 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Divulgação de trabalho: considerações sobre os doze anos do caderno de estudos

open access: yesRevista Contabilidade & Finanças, 2002
Este artigo tem o propósito de apresentar uma avaliação do periódico corrente Caderno de Estudos, atual Revista Contabilidade & Finanças - USP, publicado pela Fundação Instituto de Pesquisas Contábeis, Atuariais e Financeiras -FIPECAFI, entidade de apoio
Gilberto de Andrade Martins
doaj   +1 more source

Modelling Unobserved Heterogeneity in Claim Counts Using Finite Mixture Models

open access: yesRisks, 2020
When modelling insurance claim count data, the actuary often observes overdispersion and an excess of zeros that may be caused by unobserved heterogeneity.
Lluís Bermúdez   +2 more
doaj   +1 more source

The Role of the Actuary in the National Health Services [PDF]

open access: yes, 1996
The paper discusses the role of actuaries within the NHS. Actuaries have applied the concept of Geographic Information Systems to health data on patient traffic flows, transportation studies and specialty specific information on NHS providers (such as ...
G.C. Orros
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

THE ROLE AND SIGNIFICANCE OF THE CREDIBILITY THEORY IN ACTUARIAL PRACTICE

open access: yesPravo, 2014
Actuarial science is based on the use of financial and statistical models and depends on the practical framework, starting from the operation of the insurance market through the accounting system and the available data.
Nataša Papić Blagojević   +1 more
doaj  

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