Results 61 to 70 of about 3,093 (299)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Clinical Versus Actuarial Judgment
Science, 1989 Professionals are frequently consulted to diagnose and predict human behavior; optimal treatment and planning often hinge on the consultant's judgmental accuracy. The consultant may rely on one of two contrasting approaches to decision-making—the clinical and actuarial methods.
R M, Dawes, D, Faust, P E, Meehl
openaire +2 more sources
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Advances in Difference Equations, 2018 The exact solution of fractional combined Korteweg-de Vries and modified Korteweg-de Vries (KdV–mKdV) equation is obtained by using the (1/G′) $(1/G^{\prime})$ expansion method.
Doğan Kaya +3 more
doaj +1 more source
Kerangka konsep penubuhan Jabatan Aktuari Negara di Malaysia [A conceptual framework for the establishment of a Government Actuary?s Department in Malaysia] [PDF]
, 2015 The profession of an actuary is very important towards the society. Actuaries and actuarial scientists employ their skills of mathematics and statistics to measure the financial implication of future events by consideration the risk factors.
Hasim, H
core
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
A framework for the regulation of long-term insurers : solvency assessment and the role of the statutory actuary [PDF]
, 2012 In this dissertation the theory of solvency assessment for long-term insurers is reviewed and how it evolved. Key international bodies and standards are identified and selected jurisdictions’ solvency frameworks are reviewed.
Viljoen, Dirk Johannes
core
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source