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Liver Transplantation in Acute-on-Chronic Liver Failure
Clinics in Liver Disease, 2023In recent years there has been a significant increase in the incidence of acute-on-chronic liver failure (ACLF). This syndrome is characterized by infections, organ failures, and high short-term mortality. Although progress in the management of these sick patients has been evident, liver transplantation (LT) remains the best treatment modality to date.
Anand V, Kulkarni, K Rajender, Reddy
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Liver Regeneration in Acute on Chronic Liver Failure
Clinics in Liver Disease, 2023Liver regeneration is a multifaceted process by which the organ regains its original size and histologic organization. In recent decades, substantial advances have been made in our understanding of the mechanisms underlying regeneration following loss of hepatic mass.
Madelyn J, Blake, Clifford J, Steer
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Acute on Chronic Liver Failure
Ugeskrift for laeger, 2019Acute on chronic liver failure (ACLF) describes a clinical syndrome characterized by (1) a patient with chronic liver disease that develops a (2) new or worsening hepatic decompensation with (3) marked dysfunction of other extrahepatic organs and (4) an increased short-term mortality.
Mark R. Pedersen, Shannan R. Tujios
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Acute on chronic liver failure
Gastroenterología y Hepatología, 2010Acute-on-Chronic Liver Failure (ACLF) is a recently introduced term defined as severe acute deterioration of an established liver disease. This entity usually develops after an acute insult. The main clinical manifestations are hepatorenal syndrome, hepatic encephalopathy and organ failure, with a high risk of death in the short term.
Angels, Escorsell Mañosa +1 more
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Liver Transplantation in Acute-on-chronic Liver Failure
Transplantation, 2020Liver transplantation (LT) has revolutionized outcomes for cirrhotic patients. Current liver allocation policies dictate patients with highest short-term mortality receive the highest priority, thus, several patients become increasingly ill on the waitlist.
Constantine J, Karvellas +2 more
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Pro: Acute‐on‐chronic liver failure
Liver Transplantation, 2017Liver Transplantation 23 1318–1324 2017 AASLD.
Solà, Elsa, Ginès, Pere
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Acute-on-Chronic Liver Failure
2021In the last two decades, a new concept of acute-on-chronic liver failure (ALCF) has emerged as a distinctive condition compared to decompensated cirrhosis. ACLF is associated with excessive systemic inflammatory response in patients with underlying chronic liver disease, leading to acute deterioration of liver function, multi-organ failure, as well as ...
Marie-Eve Chartier, Fernando Alvarez
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Acute-on-Chronic Liver Failure
American Journal of Gastroenterology, 2022Jasmohan S, Bajaj +4 more
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Management of Acute-on-Chronic Liver Failure
Seminars in Liver Disease, 2016Acute-on-chronic liver failure (ACLF) is defined by the occurrence of organ failure(s) other than the liver in patients with cirrhosis. Even though mortality rates are high, there should no longer be reluctance to admit patients with ACLF in the intensive care unit.
Francois, Durand, Mitra K, Nadim
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