Results 81 to 90 of about 478,633 (337)

Use of OKT3 with ciclosporin and steroids for reversal of acute kidney and liver allograft rejection [PDF]

, 1987
OKT3 monoclonal antibody therapy was added to preexisting baseline immunosuppressive treatment with ciclosporin and steroids to treat rejection in 52 recipients of cadaveric livers and 10 recipients of cadaveric kidneys.
Demetris, AJ, Fung, JJ, Porter, KA
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Galectin-3. One molecule for an alphabet of diseases, from A to Z [PDF]

, 2018
Galectin-3 (Gal-3) regulates basic cellular functions such as cell–cell and cell–matrix interactions, growth, proliferation, differentiation, and inflammation.
Bellotti, Carlo, De Francesco, Gian Paolo, Lavra, Luca, Magi, Fiorenza, Morgante, Alessandra, Ricci, Alberto, Salehi, Leila B., Sciacchitano, Salvatore, Ulivieri, Alessandra   +8 more
core   +2 more sources

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Acute-on-Chronic Liver Failure: Recent Concepts [PDF]

Journal of Clinical and Experimental Hepatology, 2015
A proportion of patients hospitalized for an acute complication of cirrhosis are at high risk of short-term death. The term Acute-on-Chronic Liver Failure (ACLF) is used to characterize these patients. Until recently there was no evidence-based definition of ACLF.
Richard, Moreau, Rajiv, Jalan, Vicente, Arroyo   +2 more
openaire   +2 more sources

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Bacterial Infections in End-Stage Liver Disease: Implications for Liver Transplantation

Transplantology
Bacterial infections are a common complication in patients with decompensated liver cirrhosis. The complex landscape of cirrhosis, characterized by immune paralysis and an exhausted response to exogenous triggers, explains the higher prevalence of such ...
Alberto Ferrarese, Marco Senzolo, Anna Maria Cattelan, Lolita Sasset, Sara Battistella, Alberto Zanetto, Giacomo Germani, Francesco Paolo Russo, Martina Gambato, Filippo Pelizzaro, Stefania Vio, Domenico Bassi, Umberto Cillo, Patrizia Burra   +13 more
doaj   +1 more source

Predictive Scores for Mortality in MAFLD-Related Acute-on-Chronic Liver Failure (MAFLD-ACLF): Development and Validation of MAFLD-MELD-Na and MAFLD-AARC Scores. [PDF]

, 2023
Ashish Kumar, Shiv Kumar Sarin, Anil Arora, Ashok Choudhury, Vinod Arora, Mohamed Rela, Dinesh Jothimani, Mamun Al Mahtab, Harshad Devarbhavi, CE Eapen, Ashish Goel, César Yaghi, Qin Ning, Tao Chen, Jidong Jia, Zhongping Duan, Saeed Hamid, Amna Subhan Butt, Syed Muhammad Wasim Jafri, Akash Shukla, Seok Siam Tan, Dong Joon Kim, Anoop Saraya, Jinhua Hu, Ajit Sood, Omesh Goyal, Vandana Midha, Manoj Kumar Sahu, Guan Huei Lee, Sombat Treeprasertsuk, Kessarin Thanapirom, Ameet Mandot, Ravikiran Maghade, Laurentius A. Lesmana, Hasmik Ghazinyan, V. G. Mohan Prasad, A. Kadir Dökmeci, Jose D. Sollano, Zaigham Abbas, Ananta Shrestha, George Lau, Diana A. Payawal, Gamal Shiha, Ajay Duseja, Sunil Taneja, Nipun Verma, Padaki Nagaraja Rao, Anand V. Kulkarni, Fazal Karim, Vivek A. Saraswat, Shahinul Alam, Osamu Yokosuka, Debashis Chowdhury, Chandan Kumar Kedarisetty, Sanjiv Saigal, Praveen Sharma, Babita Prasad, Ghulam Nabi Yattoo, Abraham Koshy, Ajay Kumar Patwa, Mohamed Elbasiony, Pravin Rathi, Sudhir Maharshi, Vishwa Mohan Dayal, Ashish Kumar Jha, Kemal Fariz Kalista, Rino Alvani Gani, Man‐Fung Yuen, Virendra Singh, Ayaskanta Singh, Sargsyan Violeta, Chien‐Hao Huang, Saurabh Mukewar, Shaojie Xin, Ruveena Bhavani Rajaram, Charles Panackel, Sunil Dadhich, Sanjeev Sachdeva, Sanatan Behera, Lubna Kamani, Hemamala Venugopal Saithanyamurthi   +80 more
openalex   +1 more source

M2-like macrophages in the fibrotic liver protect mice against lethal insults through conferring apoptosis resistance to hepatocytes. [PDF]

, 2017
Acute injury in the setting of liver fibrosis is an interesting and still unsettled issue. Most recently, several prominent studies have indicated the favourable effects of liver fibrosis against acute insults.
Bai, Li, Chen, Yu, Duan, Zhongping, Han, Yuan-Ping, Hu, Richard, Kong, Ming, Liu, Shuang, Liu, Xin, Lou, Jinli, Pandol, Stephen J, Ren, Feng, Zhang, Xiaohui, Zheng, Qingfen, Zheng, Sujun   +13 more
core   +2 more sources

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source