Results 31 to 40 of about 7,222,965 (284)
Association of the transthyretin variant V122I with polyneuropathy among individuals of African ancestry
Scientific Reports, 2021 Hereditary transthyretin-mediated (hATTR) amyloidosis is an underdiagnosed, progressively debilitating disease caused by mutations in the transthyretin (TTR) gene.Margaret M. Parker, Scott M. Damrauer, Catherine Tcheandjieu, David Erbe, Emre Aldinc, Philip N. Hawkins, Julian D. Gillmore, Leland E. Hull, Julie A. Lynch, Jacob Joseph, Simina Ticau, Alexander O. Flynn-Carroll, Aimee M. Deaton, Lucas D. Ward, Themistocles L. Assimes, Philip S. Tsao, Kyong-Mi Chang, Daniel J. Rader, Kevin Fitzgerald, Akshay K. Vaishnaw, Gregory Hinkle, Paul Nioi +21 moredoaj +1 more sourceC. elegans feed yolk to their young in a form of primitive lactation
Nature Communications, 2021 It is unclear why C. elegans continues to produce large quantities of yolk after reproduction. Here the authors show that post-reproductive C. elegans mothers vent yolk which supports their offspring’s growth, serving as a form of primitive lactation.Carina C. Kern, StJohn Townsend, Antoine Salzmann, Nigel B. Rendell, Graham W. Taylor, Ruxandra M. Comisel, Lazaros C. Foukas, Jürg Bähler, David Gems +8 moredoaj +1 more sourceProteomic Analysis for the Diagnosis of Fibrinogen Aα-chain Amyloidosis
Kidney International Reports, 2019 Introduction: Hereditary fibrinogen Aα-chain (AFib) amyloidosis is a relatively uncommon renal disease associated with a small number of pathogenic fibrinogen Aα (FibA) variants; wild-type FibA normally does not result in amyloid deposition.Graham W. Taylor, Janet A. Gilbertson, Rabya Sayed, Angel Blanco, Nigel B. Rendell, Dorota Rowczenio, Tamer Rezk, P. Patrizia Mangione, Diana Canetti, Paul Bass, Philip N. Hawkins, Julian D. Gillmore +11 moredoaj +1 more sourceOptimal combinations of acute phase proteins for detecting infectious disease in pigs [PDF]
, 2011 Peer ...Mathilda JM Toussaint, Eckersall, P.D., Anders Stockmarr, Campbell, Fiona M, Rakel Carpintero, Piñeiro, M., Toussaint, Mathilda J.M., Sorensen, N., Eckersall, P. David, Campbell, F.M., Nanna Sorensen, Campbell, Fiona Margaret, Toussaint, M.J.M., Carpintero, Rakel, Fiona M Campbell, Lampreave, F., Skall Sorensen, Nanna, P Eckersall, Carpintero, R., Erik Gruys, Piñeiro, Matilde, Heegaard, P.M.H., Fermin Lampreave, Stockmarr, A., Toussaint, Mathilda JM, Lampreave, Fermin, Sørensen, Nanna Skall, Matilde Piñeiro, Heegaard, Peter M. H., Peter MH Heegaard, Gruys, Erik, Gruys, E., Eckersall, P David, Stockmarr, Anders, Lampreave Fermin, Eckersall P, Stockmarr Anders, Sorensen Nanna, Gruys Erik, Carpintero Rakel, Heegaard Peter MH, Campbell Fiona M, Piñeiro Matilde, Toussaint Mathilda JM +43 morecore +1 more sourceGenome-Wide Association Study Identifies Two Novel Regions at 11p15.5-p13 and 1p31 with Major Impact on Acute-Phase Serum Amyloid A [PDF]
, 2010 Elevated levels of acute-phase serum amyloid A (A-SAA) cause amyloidosis and are a risk factor for atherosclerosis and its clinical complications, type 2 diabetes, as well as various malignancies.Illig, T, Spector Tim D., Kleber, M.E., März Winfried, Wichmann, H. -Erich, Mangino, M, Waldenberger, M, Hammond Christopher J., Prokopenko, I, Hammond, Christopher J., Blackburn Hannah, Prokisch Holger, Winkelmann Bernhard R., Mangino, M., H.-Erich Wichmann, Kovacs, P., Wichmann, H.-E., Marzi, C, Illig, T., Waldenberger, Melanie, Tim D Spector, Geistlinger, Ludwig, Tönjes, A, Koenig Wolfgang, Peters, Annette, Thorand, Barbara, Illig Thomas, Boehm, Bernhard O., Toenjes, Anke, Peters Annette, Boehm Bernhard O., Hysi, P.G., Kovacs, Peter, Prokisch, H., Mangino Massimo, Marcus E Kleber, Annette Peters, Prokopenko, I., Pirro G. Hysi, Soranzo, Nicole, Christopher J. Hammond, Hysi, Pirro G., Koenig, W, Tönjes Anke, Hammond, C.J., Heim, K., Harald Grallert, H-Erich Wichmann, Bernhard O. Boehm, Marzi, C., Koenig, W., Gieger, Christian, Eva Albrecht, Soranzo, N, Hammond, CJ, Albrecht Eva, Hysi Pirro G., Vasiliki Lagou, Grallert, H., Koenig, Wolfgang, Nicole Soranzo, Spector, Tim D., Gieger, C, Marz, W., Melanie Waldenberger, Michael Stumvoll, Thorand Barbara, Hysi, PG, Boehm, BO, Carola Marzi, Boehm, B.O., Janina S Ried, Lagou, Vasiliki, Wichmann, Heinz-Erich, Bernhard R. Winkelmann, Inga Prokopenko, Hannah Blackburn, Heim, Katharina, Kleber, ME, Peters, A, Stumvoll, M, Anke Tönjes, März, W, Gieger, C., Ried, Janina S., Christian Gieger, Ried, JS, Bernhard O Boehm, Albrecht, E, Blackburn, H, Stumvoll, M., Pirro G Hysi, Lagou Vasiliki, Ried Janina S., Waldenberger Melanie, Thorand, B, Christopher J Hammond, Lagou, V, Gieger Christian, Blackburn, Hannah, Grallert, Harald, Heim, K, Kleber Marcus E., Prokopenko Inga, Spector, T.D., Marzi, Carola, Waldenberger, M., Winkelmann, B.R., Heim Katharina, Wichmann H.-Erich, Kleber, Marcus E., Wolfgang Koenig, Barbara Thorand, Tönjes, A., Soranzo, N., Winfried März, Prokisch, Holger, Stumvoll, Michael, Marcus E. Kleber, Tim D. Spector, Mangino, Massimo, Stumvoll Michael, Grallert, H, Wichmann, HE, Geistlinger, L, Peters, A., Illig, Thomas, Maerz, Winfried, Ried, J.S., Grallert Harald, Thomas Illig, Albrecht, Eva, Lagou, V., Bernhard R Winkelmann, Kovacs Peter, Geistlinger Ludwig, Kovacs, P, Prokisch, H, Prokopenko, Inga, Katharina Heim, Marzi Carola, Soranzo Nicole, Massimo Mangino, Ludwig Geistlinger, Geistlinger, L., Blackburn, H., Peter Kovacs, Spector, TD, Janina S. Ried, Albrecht, E., Thorand, B., Winkelmann, BR, Winkelmann, Bernhard R., Holger Prokisch, Marzi, C;Albrecht, E;Hysi, PG;Lagou, V;Waldenberger, M;Tönjes, A;Prokopenko, I;Heim, K;Blackburn, H;Ried, JS;Kleber, ME;Mangino, M;Thorand, B;Peters, A;Hammond, CJ;Grallert, H;Boehm, BO;Kovacs, P;Geistlinger, L;Prokisch, H;Winkelmann, BR;Spector, TD;Wichmann, HE;Stumvoll, M;Soranzo, N;März, W;Koenig, W;Illig, T;Gieger, C +154 morecore +2 more sourcesRenal Amyloidosis Associated With 5 Novel Variants in the Fibrinogen A Alpha Chain Protein
Kidney International Reports, 2017 Fibrinogen A alpha chain amyloidosis is an autosomal dominant disease associated with mutations in the fibrinogen A alpha chain (FGA) gene, and it is the most common cause of hereditary renal amyloidosis in the UK.Dorota Rowczenio, Maria Stensland, Gustavo A. de Souza, Erik H. Strøm, Janet A. Gilbertson, Graham Taylor, Nigel Rendell, Shane Minogue, Yvonne A. Efebera, Helen J. Lachmann, Ashutosh D. Wechalekar, Philip N. Hawkins, Ketil R. Heimdal, Kristian Selvig, Inger K. Lægreid, Nathalie Demoulin, Selda Aydin, Julian D. Gillmore, Tale N. Wien +18 moredoaj +1 more sourceInhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel
Scientific Reports, 2017 Dissociation of the native transthyretin (TTR) tetramer is widely accepted as the critical step in TTR amyloid fibrillogenesis. It is modelled by exposure of the protein to non-physiological low pH in vitro and is inhibited by small molecule compounds ...Guglielmo Verona, P. Patrizia Mangione, Sara Raimondi, Sofia Giorgetti, Giulia Faravelli, Riccardo Porcari, Alessandra Corazza, Julian D. Gillmore, Philip N. Hawkins, Mark B. Pepys, Graham W. Taylor, Vittorio Bellotti +11 moredoaj +1 more sourceEfficacy of bortezomib, cyclophosphamide and dexamethasone in treatment-naïve patients with high-risk cardiac AL amyloidosis (Mayo Clinic stage III)
Haematologica, 2014 Bortezomib is an active agent in AL amyloidosis and responses to this drug in combination with cyclophosphamide and dexamethasone are both rapid and deep.Arnaud Jaccard, Raymond L. Comenzo, Parameswaran Hari, Philip N. Hawkins, Murielle Roussel, Pierre Morel, Margaret Macro, Jean-Luc Pellegrin, Estibaliz Lazaro, Dania Mohty, Patrick Mercie, Olivier Decaux, Julian Gillmore, David Lavergne, Frank Bridoux, Ashutosh D. Wechalekar, Christopher P. Venner +16 moredoaj +1 more source
