Results 61 to 70 of about 7,222,965 (284)

Acute Phase Proteins in Marine Mammals: State of Art, Perspectives and Challenges

Frontiers in Immunology, 2019
The term “acute phase response” (APR) is referred to a nonspecific and complex reaction of an organism that occurs shortly after any tissue damage, such as infection, trauma, neoplasia, inflammation, and stress.
Maria Elena Gelain, Federico Bonsembiante, Federico Bonsembiante   +2 more
doaj   +1 more source

Acute-phase proteins in osteoarthritis

Seminars in Arthritis and Rheumatism, 1995
The joint destruction of osteoarthritis (OA) comprises loss of articular cartilage resulting from an imbalance of enzyme-catalized cartilage breakdown and regeneration. OA is thought to derive from defective chondrocyte metabolism and thus to inherently lack the large-scale systemic response that is the hallmark of rheumatoid arthritis (RA). Because of
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Determination of some acute phase proteins, biochemical parameters and oxidative stress in sheep with naturally infected sheeppox virus [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2018
The aim of the present study was to determine oxidative stress and acute phase response in naturally infected sheep with poxvirus. For this purpose, 20 poxvirus infected and 10 clinically healthy sheep were used in the study.
Kadir BOZUKLUHAN, Oğuz MERHAN, Halil İbrahim GÖKÇE, Metin ÖĞÜN, Emine ATAKİŞİ, Şemistan KIZILTEPE, Gürbüz GÖKÇE   +6 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function [PDF]

, 2010
Acute-phase proteins (APPs) are an evolutionarily conserved family of proteins produced mainly in the liver in response to infection and inflammation.
Beraza, N., Linke, Reinhold P, Dierssen, U., Magarian Blander, J., Magarian Blander, Julie, Linke, R., Müller, M.R., Sander, Leif E., Leif E. Sander, Sander, L.E., Christian Trautwein, Dierssen, Uta, Trautwein, Christian, Sara Dutton Sackett, Sander, Leif Erik, Reinhold P. Linke, Müller, Michael, Tacke, F., Dutton Sackett, Sara, Tacke, Frank, Beraza, Naiara, Blander, J Magarian, Michael Müller, Uta Dierssen, Naiara Beraza, Frank Tacke, Sackett, S.D., Sackett, Sara Dutton, Blander, J.M., Trautwein, C., Sander, Leif E, J. Magarian Blander, Linke, Reinhold P.   +32 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The M, E, and N structural proteins of the severe acute respiratory syndrome coronavirus are required for efficient assembly, trafficking, and release of virus-like particles [PDF]

, 2008
Copyright @ 2008 American Society for Microbiology.The production of virus-like particles (VLPs) constitutes a relevant and safe model to study molecular determinants of virion egress.
Kien, F., Nicholls, JM, Bruzzone, R, Chan, C. M., Tsao, SW, Kien, F, Siu, Y. L., Escriou, N, Altmeyer, R., Nal, B., Nicholls, J. M., Chan, CM, Siu, YL, Lo, J, Peiris, J. S. M., Tsao, S. W., Teoh, KT, Nal, B, Teoh, K. T., Peiris, JSM, Altmeyer, R, Lo, J., Escriou, N., Bruzzone, R.   +23 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source