Results 131 to 140 of about 3,859,259 (322)
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
Molecular Oncology, EarlyView.CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan +10 more
wiley +1 more source
The Moduli Space of Acute Triangles [PDF]
Notices Amer. Math. Soc. 71 (2024), 664-665As an introduction to the concept of "moduli space" we consider the moduli space of similarity classes of acute and right triangles in the plane. This has a map to the moduli space of elliptic curves which is onto and generically three-to-one. The reason is that from any acute or right triangle we can construct an elliptic curve, and every elliptic ...
arxiv
Specimen showing Carcinoma of the Pelvic Colon and Rectum co-existing and causing Acute Obstruction. [PDF]
, 1922 Charles Gordon‐Watson
openalex +1 more source
Molecular Oncology, EarlyView.Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka +10 more
wiley +1 more source
Vision-Language Models for Acute Tuberculosis Diagnosis: A Multimodal Approach Combining Imaging and Clinical Data [PDF]
arXivBackground: This study introduces a Vision-Language Model (VLM) leveraging SIGLIP and Gemma-3b architectures for automated acute tuberculosis (TB) screening. By integrating chest X-ray images and clinical notes, the model aims to enhance diagnostic accuracy and efficiency, particularly in resource-limited settings.
arxiv