Results 181 to 190 of about 7,815,815 (291)

Transforming post-acute pneumonia management: risk stratification using machine learning. [PDF]

ERJ Open Res
Cilloniz C, Mogensen ML, Ward L.
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The State of Hepatitis B in Florida in 2025: Current Challenges and Health Disparities. [PDF]

J Viral Hepat
Nejat C.
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Trends, Treatment Approaches, and In-Hospital Mortality for Acute Coronary Syndrome in Japan During the Coronavirus Disease 2019 Pandemic

, 2021
Tetsuji Morishita, Daisuke Takada, Jung‐ho Shin, T. Higuchi, Susumu Kunisawa, Yuichi Imanaka   +5 more
openalex   +2 more sources

Predictors and outcomes of acute respiratory failure in hospitalised patients with acute pancreatitis [PDF]

, 2020
Mahesh Gajendran, Bharat Prakash, Abhilash Perisetti, Chandraprakash Umapathy, Vineet Gupta, Laura C. Collins, Prashanth Rawla, Priyadarshini Loganathan, Alok Dwivedi, Christopher Dodoo, Fortune Unegbu, Dan Schuller, Hemant Goyal, Shreyas Saligram   +13 more
openalex   +1 more source

Naldemedine for the Prevention of Recurrent Acute Pancreatitis: A Randomised, Double-Blind, Placebo-Controlled Trial. [PDF]

United European Gastroenterol J
Cook ME, Knoph CS, Davidsen L, Frøkjær JB, Bruun NH, Novovic S, Hadi A, Jørgensen MT, Mortensen MB, Schaffalitzky O, Nielsen LBJ, Berner-Hansen M, Drewes AM, Olesen SS.   +13 more
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Variations in Managing Acute Spinal Cord Injury in the North American Clinical Trials Network and Partner Institutes. [PDF]

Global Spine J
Gebeyehu TF, Sokol Z, Guest JD, Harrington JD, Kabani AS, Fitchett E, Lopez A, Matsoukas S, Franco D, Jallo J, Vaccaro AR, Abd-El-Bar M, Kurpad SN, Tator CH, Fehlings MG, Harrop J.   +15 more
europepmc   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source