Results 191 to 200 of about 7,815,815 (291)

COVID-19−Associated Acute Kidney Injury and Longitudinal Kidney Outcomes

Abinet M. Aklilu, Sanchit Kumar, James T. Nugent, Yu Yamamoto, Claudia Coronel-Moreno, Bashar Kadhim, Sophia Faulkner, Kyle O’Connor, Farah Yasmin, Jason H. Greenberg, Dennis G. Moledina, Jeffrey M. Testani, F. Perry Wilson   +12 more
openalex   +2 more sources

Factors that influence acute malnutrition detection and treatment by community health promoters in Samburu and Turkana counties, Kenya: A mixed methods study. [PDF]

PLOS Glob Public Health
Ng'ang'a MN, Thuita F, Ngari M, Webale A, Macharia T, Eris S, Wafula G, Lomoru L, Mukoma R, Mohamed H, Flax VL.   +10 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Acute‐phase protein serum amyloid A3 is a novel paracrine coupling factor that controls bone homeostasis [PDF]

, 2014
Roman Thaler, Ines Sturmlechner, Silvia Spitzer, Scott M. Riester, M. Rumpler, Jochen Zwerina, Klaus Klaushofer, André J. van Wijnen, Franz Varga   +8 more
openalex   +1 more source

Understanding acute vertigo in emergency care in a large London teaching hospital: patient and physician perspectives on diagnostic challenges and digital support. [PDF]

BMJ Open
Cortese E, Ramsay AIG, Koohi N, Kaski D.
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Same disease, different outcomes: a retrospective cohort study of COVID-19-associated AKI across Brazil's dual-tiered healthcare system. [PDF]

J Bras Nefrol
Faria NP, Suassuna JHR, Sousa CAM, Freire SM, Gomes CLR.   +4 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The correlational study of the 24 solar terms and meteorological factors with the acute exacerbation of bipolar disorder. [PDF]

Compr Psychoneuroendocrinol
Chen J, Wu T, Wu H, Zhou J, Li W.
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source