Results 61 to 70 of about 8,348,024 (289)

Selective allodepletion to improve anti-viral and anti-leukaemic responses after haploidentical transplantation [PDF]

, 2009
Immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical SCT, but infection and leukaemic relapse remain problematic.
Samarasinghe, S, Samarasinghe, S.
core  

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, EarlyView.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source

Acute graft-versus-host disease in thalassaemic marrow transplantation with low-dose antithymocyte globulin [PDF]

, 1999
465-469Our unit performed transplantations on 21 classes II and III thalassaemic patients [class II patients had either hepatomegaly or portal fibrosis and class III patients had both]. We used busulfan [15 mg/kg] and cyclophosphamide [200 mg/kg].
Khojasteh, H.N.
core  

Chemical Strategies for Multistimuli Responsive Dynamic Covalent Materials in Regenerative Medicine

Advanced Healthcare Materials, EarlyView.
Multistimuli responsive dynamic covalent materials integrate reversible chemistry with the complex chemical, mechanical, and biochemical cues of regenerative environments. This review highlights chemical strategies based on orthogonal dynamic bonds, multicomponent networks, and hierarchical architectures to regulate mechanics, degradation, and ...
Saurabh Joshi, Matthew B. Baker, Dominik Schauenburg   +2 more
wiley   +1 more source

A molecular and computational diagnostic approach identifies FOXP3, ICOS, CD52 and CASP1 as the most informative biomarkers in acute graft-versus-host disease

Haematologica, 2012
Background Acute graft-versus-host disease is a severe complication of allogeneic stem cell transplantation in which the functional immune cells of the donor recognize the recipient as foreign and mount an immunological attack.
Maria Cuzzola, Maurizio Fiasché, Pasquale Iacopino, Giuseppe Messina, Massimo Martino, Giuseppe Console, Roberta Fedele, Daniela Massi, Anna Grazia Recchia, Giuseppe Irrera, Fortunato Morabito   +10 more
doaj   +1 more source

Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune‐Shielded Heart Valves

Advanced Healthcare Materials, EarlyView.
Living donor heart valves offer superior durability for pediatric patients but trigger immune rejection. Lentiviral delivery of viral immune‐evasion genes US2 and Serpin b9 into donor valve cells and valve tissue suppresses HLA expression, reduces PBMC clustering and cytotoxic killing, and induces transcriptional immune‐tolerance programs, paving the ...
Abraham van Wijk, Leanne Van den Berg, Isa B. M. Velraeds, Valentina Osorio Zuluaga, Emma T. M. Peereboom, Martijn J. W. E. Rabelink, Arnaud Zaldumbide, Rob C. Hoeben, Marie‐Jose T. H. Goumans, Eric Spierings, Carlijn V. C. Bouten, Marijn C. Peters   +11 more
wiley   +1 more source

Backgrounds of patients with acute gastrointestinal graft-versus-host disease or infectious colitis.

, 2018
Backgrounds of patients with acute gastrointestinal graft-versus-host disease or infectious colitis.
Gota Sudo (5570936), Daisuke Hirayama (4396837), Tomoya Iida (4732995), Toshiyuki Kubo (5570939), Masanori Nojima (52788), Hiroo Yamano (5570942), Kentaro Yamashita (796584), Hiroshi Nakase (783451), Sae Ohwada (5570933)   +8 more
core   +1 more source

Human iPSC‐Derived Tissue‐Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model

Advanced Healthcare Materials, EarlyView.
Inspired by conventional cell therapy and emerging bioengineering approaches, the tissue‐engineered nigrostriatal pathway (TE‐NSP) has an anatomically‐inspired design comprising a population of human dopaminergic neurons with unidirectional, long‐projecting axon tracts.
Wisberty J. Gordián‐Vélez, Dimple Chouhan, Kevin D. Browne, James Lim, Saarang P. Karandikar, Rodrigo A. España, John E. Duda, H. Isaac Chen, D. Kacy Cullen   +8 more
wiley   +1 more source

Extracorporeal photopheresis as second-line treatment for acute graft-versus-host disease: impact on six-month freedom from treatment failure

Haematologica, 2014
Second-line therapy for corticosteroid-refractory or -dependent acute graft-versus-host disease remains ill-defined, due to limited efficacy of drugs and evolving clinical trial endpoints.
Emma Das-Gupta, Hildegard Greinix, Ryan Jacobs, Li Zhou, Bipin N. Savani, Brian G. Engelhardt, Adetola Kassim, Nina Worel, Robert Knobler, Nigel Russell, Madan Jagasia   +10 more
doaj   +1 more source

HTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantation

Nature Communications, 2022
Acute graft versus host disease is a rare but deadly complication following liver transplantation. Author show here, upon screening a large cohort of liver transplanted patients and detailed immune phenotyping of samples from the 7 affected individuals ...
Chuan Shen, Yiyang Li, Boqian Wang, Zhipeng Zong, Tianfei Lu, Nokuzola Maboyi, Yuxiao Deng, Yongbing Qian, Jianjun Zhang, Xianting Ding, Qiang Xia   +10 more
doaj   +1 more source