Results 1 to 10 of about 359,319 (260)
Klotho as a potential biomarker and therapy for acute kidney injury [PDF]
Nature Reviews Nephrology, 2012 Klotho is a single-pass transmembrane protein that is highly expressed in the kidney and is known to act as a coreceptor for fibroblast growth factor 23. The extracellular domain can be produced independently or shed from membrane-bound Klotho and functions as an endocrine substance with multiple functions including antioxidation, modulation of ion ...
Ming Chang Hu, Orson W Moe
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Dosing of Renal Replacement Therapy in Acute Kidney Injury [PDF]
American Journal of Kidney Diseases, 2012 The impact of the intensity of renal replacement therapy on outcomes in patients with acute kidney injury has been studied intensively during the past decade. In this review, we consider the concept of dose of renal replacement therapy in acute kidney injury and summarize the recent clinical trials addressing this topic.
Anitha Vijayan, Paul M Palevsky
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Novel Therapies for Acute Kidney Injury [PDF]
Kidney International Reports, 2017 Acute kidney injury (AKI) is a common disease with a complex pathophysiology. The old paradigm of identifying renal injury based on location-prerenal, intrarenal, and postrenal-is now being supplanted with a new paradigm based on observable kidney injury patterns. The pathophysiology of AKI on a molecular and microanatomical level includes inflammation,
Huaizhen Chen, Laurence William Busse
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Timing of Kidney Replacement Therapy in Acute Kidney Injury [PDF]
Clinical Journal of the American Society of Nephrology, 2018 AKI is a common complication with an increasing incidence and a higher risk of short- and long-term complications ([1][1]). Kidney replacement therapy (KRT) is often required in patients with severe AKI who develop clinical and/or metabolic complications.
Alexander, Zarbock, Ravindra L, Mehta
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Translating Knowledge Into Therapy for Acute Kidney Injury [PDF]
Seminars in Nephrology, 2018 No therapies have been shown to improve outcomes in patients with acute kidney injury (AKI). Given the high morbidity and mortality associated with AKI this represents an important unmet medical need. A common feature of all of the therapeutic development efforts for AKI is that none were driven by target selection or preclinical modeling that was ...
Mark, de Caestecker, Raymond, Harris
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Renal Replacement Therapy for Acute Kidney Injury [PDF]
Nephron Clinical Practice, 2009 The treatment of established acute kidney injury (AKI) is largely supportive in nature. Renal replacement therapy remains the cornerstone of management for the minority of patients who have severe AKI. Optimization of renal replacement therapy may modulate the high mortality associated with AKI. Recent trials indicated that continuous renal replacement
Heather, Fieghen +2 more
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Nutrition Support in Acute Kidney Injury [PDF]
, 2011 Acute kidney injury is a frequent complication affecting many hospitalized patients and is associated with increased morbidity and mortality. Acute kidney injury often occurs in conjunction with critical illness, which is a hypermetabolic state ...
Alkhunaizi AM +15 more
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Pro/con debate: continuous versus intermittent dialysis for acute kidney injury: a never-ending story yet approaching the finish? [PDF]
, 2010 The question of whether renal replacement therapy should be applied in an intermittent or continuous mode to the patient with acute kidney injury has been the topic of several controlled studies and meta-analyses.
Vanholder, Raymond +3 more
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Impact of acute kidney injury exposure period among liver transplantation patients [PDF]
, 2013 Background: Acute kidney injury is a common complication of liver transplantation. in this single-centre retrospective observational study, we investigated the impact of acute kidney disease on liver recipient survival.Methods: the study population ...
Batista, Marcelo Costa +8 more
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Cell-Based Therapies in Acute Kidney Injury (AKI) [PDF]
Kidney and Blood Pressure Research, 2018 Acute kidney injury frequently occurs in hospitalized patients all over the world. The prognosis remains poor since specific therapies for promoting kidney regeneration/repair are still missing. In recent years cell-based strategies have improved AKI outcomes under experimental circumstances.
Patschan, Daniel +3 more
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