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Acute kidney injury due to antimicrobial therapy
Vnitřní lékařství, 2022One of the common causes of acute kidney injury (AKI) is drug nephrotoxicity. A large group of drugs associated with AKI includes a considerable number of antimicrobials. Clinical manifestations range from mild forms of tubular damage to significant deterioration of renal function requiring renal replacement therapy.
Viktor, Klementa +5 more
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Timing of kidney replacement therapy initiation in acute kidney injury
Current Opinion in Nephrology & Hypertension, 2021Purpose of review Over the past 5 years, four major randomized controlled trials were published informing our practice on the optimal timing for kidney replacement therapy (KRT) initiation in critically ill patients with acute kidney injury (AKI).
Alejandro Y, Meraz-Muñoz +2 more
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Timing of kidney replacement therapy initiation for acute kidney injury
Cochrane Database of Systematic Reviews, 2022Acute kidney injury (AKI) is a common condition among patients in intensive care units (ICUs) and is associated with high numbers of deaths. Kidney replacement therapy (KRT) is a blood purification technique used to treat the most severe forms of AKI. The optimal time to initiate KRT so as to improve clinical outcomes remains uncertain.
Fayad, Alicia Isabel +2 more
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Mitochondria-targeted therapies for acute kidney injury
Expert Reviews in Molecular Medicine, 2014Acute kidney injury (AKI) is a serious clinical condition with no effective treatment. Tubular cells are key targets in AKI. Tubular cells and, specifically, proximal tubular cells are extremely rich in mitochondria and mitochondrial changes had long been known to be a feature of AKI.
Luis Carlos, Tábara +5 more
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Renal Replacement Therapy in Pediatric Acute Kidney Injury
The Indian Journal of Pediatrics, 2020Acute kidney injury (AKI) is common in critically ill children and affects nearly 30-40% of patients admitted to the pediatric intensive care unit (ICU). Even with technological advances in critical care and dialysis, there is a high mortality rate of 66.8% to 90% in ICU patients.
Sidharth Kumar Sethi +3 more
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MEDICAL THERAPY OF ACUTE KIDNEY INJURY
Acta Clinica Belgica, 2007Pharmacologic interventions for the prevention and therapy of acute kidney injury (AKI) can be roughly divided into 2 main strategies: Optimising renal perfusion and modulation of intrarenal pathophysiological mechanisms, i.e. formation of free oxygen radicals, inflammation, tubular cast formation and renal (tubular) regeneration.
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Continuous Renal-Replacement Therapy for Acute Kidney Injury
New England Journal of Medicine, 2012Acute kidney injury develops in a 20-year-old man with Marfan's syndrome after aortic-valve replacement complicated by thoracic aortic dissection. Continuous renal-replacement therapy rather than intermittent hemodialysis is recommended because of hemodynamic instability.
FIACCADORI, Enrico +2 more
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