Results 1 to 10 of about 420,896 (315)

Understanding Quality of Life in Patients With Acute Leukemia, a Global Survey

Journal of Patient-Centered Research and Reviews, 2023
Purpose: The Acute Leukemia Advocates Network (ALAN) sought to determine which factors are most associated with poor quality of life (QoL) in patients with acute leukemia and to determine key issues and unmet needs through administration of an online ...
Zack Pemberton-Whiteley, Samantha Nier, Jan Geissler, Sophie Wintrich, Bregje Verhoeven, Rita O. Christensen, Sam Salek, Esther Natalie Oliva, Tatyana Ionova, Jennie Bradley   +9 more
doaj   +1 more source

Socioeconomic cost of AML in Sweden—A population‐based study using multiple nation‐wide registers

eJHaem, 2021
Acute myeloid leukemia (AML) is associated with a high economic and clinical burden. Recently novel therapies have been added to standard treatment regimens. Here, we evaluated the economic impact of AML up until the introduction of these novel therapies.
Emma Hernlund, Josefine Redig, Björn Paulsson, Åsa Rangert Derolf, Martin Höglund, Simona Vertuani, Gunnar Juliusson   +6 more
doaj   +1 more source

Expression of the apelinergic system and its influence on functional properties of tumor cells

Genetics & Applications, 2021
mall peptide Apelin and its cognate receptor APJ, are known to play a role in tumor angiogenesis and overall cancer progession. Certain authors suggest that the Apelin receptor is also a factor in cancer immunotherapy.
Zoran Knezevic, Jasmin Wellbrock, Frauke Fuchs, Gabi Vohwinkel, Antonia Matzat, Walter Fiedler   +5 more
doaj   +1 more source

IKZF1 deletions associate with CRLF2 overexpression leading to a poor prognosis in B-cell precursor acute lymphoblastic leukaemia

Translational Oncology, 2022
Cytokine Receptor-Like Factor 2 (CRLF2) overexpression occurs in 5-15% of B-cell precursor acute lymphoblastic leukaemia (B-ALL). In ∼50% of these cases, the mechanisms underlying this dysregulation are unknown.
Ana Luiza Tardem Maciel, Thayana da Conceição Barbosa, Caroline Barbieri Blunck, Karolyne Wolch, Amanda de Albuquerque Lopes Machado, Elaine Sobral da Costa, Lavínia Lustosa Bergier, Márcia Trindade Schramm, Maura Rosane Valério Ikoma-Coltutato, Mecneide Mendes Lins, Thais Ferraz Aguiar, Marcela Braga Mansur, Mariana Emerenciano   +12 more
doaj   +1 more source

TRANSCRIPTOME ANALYSES REVEAL NEW MARKERS FOR THE DIAGNOSIS AND TREATMENT OF KMT2A (MLL)-REARRANGED LEUKEMIA

Hematology, Transfusion and Cell Therapy, 2021
Introduction: KMT2A (MLL) gene rearrangements (KMT2A -r) are associated with diverse acute leukemias. Given the high number of KMT2A fusions, screening methods guide their detection regardless of partner gene.
BA Lopes, CP Poubel, CE Teixeira, A Caye-Eude, H Cavé, C Meyer, R Marschalek, M Boroni, M Emerenciano   +8 more
doaj   +1 more source

Improved survival outcomes and restoration of graft‐vs‐leukemia effect by deferasirox after allogeneic stem cell transplantation in acute myeloid leukemia

Cancer Medicine, 2019
Deferasirox is an oral iron‐chelating agent having possible antileukemia and immune modulatory effects. Few reports have evaluated deferasirox in the setting of allogeneic hematopoietic stem cell transplantation (allo‐HSCT). We investigated the impact of
Byung‐Sik Cho, Young‐Woo Jeon, A‐Reum Hahn, Tai‐Hyang Lee, Sung‐Soo Park, Jae‐Ho Yoon, Sung‐Eun Lee, Ki‐Seong Eom, Yoo‐Jin Kim, Seok Lee, Chang‐Ki Min, Seok‐Goo Cho, Jong‐Wook Lee, Woo‐Sung Min, Hee‐Je Kim   +14 more
doaj   +1 more source

UNEXPECTED CONCOMITANCE OF ETV6-RUNX1 AND BCR-ABL1P210 IN A CHILD WITH B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA

Hematology, Transfusion and Cell Therapy, 2021
ETV6-RUNX1 and BCR-ABL1 are recurrent primary events in pediatric B-cell precursor acute lymphoblastic leukemia (B-ALL), being the former the most common one.
TC Barbosa, ALT Maciel, E Oliveira, ES Costa, CW Almeida, ST Rouxinol, M Emerenciano   +6 more
doaj   +1 more source

The impact of HLA-matching on reduced intensity conditioning regimen unrelated donor allogeneic stem cell transplantation for acute myeloid leukemia in patients above 50 years—a report from the EBMT acute leukemia working party

Journal of Hematology & Oncology, 2016
Background Data comparing fully matched and mismatched-unrelated-donor (M- and mM-URD) allogeneic hematopoietic stem cell transplant (allo-SCT) following reduced intensity conditioning regimens for acute myeloid leukemia are limited.
Marie T. Rubio, Bipin N. Savani, Myriam Labopin, Emmanuelle Polge, Dietger Niederwieser, Arnold Ganser, Rainer Schwerdtfeger, Gerhard Ehninger, Jürgen Finke, Arnold Renate, Charles Craddock, Nicolaus Kröger, Michael Hallek, Pavel Jindra, Mohamad Mohty, Arnon Nagler   +15 more
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Genomic breakpoint-specific monitoring of measurable residual disease in pediatric non-standard-risk acute myeloid leukemia

Haematologica, 2023
Pediatric acute myeloid leukemia (AML) is a highly heterogeneous disease making standardized measurable residual disease (MRD) assessment challenging. Currently, patient-specific DNA-based assays are only rarely applied for MRD assessment in pediatric ...
Margarita Maurer-Granofszky, Stefan Kohrer, Susanna Fischer, Angela Schumich, Karin Nebral, Patrizia Larghero, Claus Meyer, Astrid Mecklenbrauker, Nora Muhlegger, Rolf Marschalek, Oskar A. Haas, Renate Panzer-Grumayer, Michael N. Dworzak   +12 more
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Similar outcomes following non-first-degree and first-degree related donor haploidentical hematopoietic cell transplantation for acute leukemia patients in complete remission: a study from the Global Committee and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Journal of Hematology & Oncology, 2023
There are situations where non-first-degree (NFD) related donors have to be considered as alternatives to first-degree (FD) related donors for haploidentical hematopoietic cell transplantation (HAPLO).
Yishan Ye, Myriam Labopin, Jia Chen, Zafer Gulbas, Xi Zhang, Yener Koc, Didier Blaise, Fabio Ciceri, Emmanuelle Polge, Mohamed Houhou, Lin Li, Yi Luo, Depei Wu, He Huang, Mohamad Mohty, Norbert-Claude Gorin   +15 more
doaj   +1 more source