Results 1 to 10 of about 395,681 (217)
Endoreduplication in Acute Leukemia [PDF]
Blood, 1963 Abstract Chromosome studies were carried out on two occasions during the evolution of a case of acute myeloblastic leukemia. A normal karyotype was detected before treatment was started. A second analysis made while the patient was under treatment with 6-mercaptopurine showed a modal number of 44 chromosomes plus a small fragment.
Cássio Bottura, Íris Ferrari
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Understanding Quality of Life in Patients With Acute Leukemia, a Global Survey
Journal of Patient-Centered Research and Reviews, 2023 Purpose: The Acute Leukemia Advocates Network (ALAN) sought to determine which factors are most associated with poor quality of life (QoL) in patients with acute leukemia and to determine key issues and unmet needs through administration of an online ...
Zack Pemberton-Whiteley +9 more
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Socioeconomic cost of AML in Sweden—A population‐based study using multiple nation‐wide registers
eJHaem, 2021 Acute myeloid leukemia (AML) is associated with a high economic and clinical burden. Recently novel therapies have been added to standard treatment regimens. Here, we evaluated the economic impact of AML up until the introduction of these novel therapies.
Emma Hernlund +6 more
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Expression of the apelinergic system and its influence on functional properties of tumor cells
Genetics & Applications, 2021 mall peptide Apelin and its cognate receptor APJ, are known to play a role in tumor angiogenesis and overall cancer progession. Certain authors suggest that the Apelin receptor is also a factor in cancer immunotherapy.
Zoran Knezevic +5 more
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Acute Promyelocytic Leukemia [PDF]
Cancers, 2020 Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) cytogenetically characterized by a balanced reciprocal translocation between chromosomes 15 and 17, which results in the fusion between the promyelocytic leukemia (PML) gene and retinoic acid receptor-α (RARα) [...]
Xavier Thomas, Maël Heiblig
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Focus on acute leukemias [PDF]
Cancer Cell, 2002 Progress toward cure of acute leukemia is likely to occur with new therapies directed at specific molecular targets, such as BCR/ABL, FLT3, RAS, and the NCor/HDAC complex. This goal may be facilitated by modern genomic approaches to acute leukemia, including use of DNA microarray and proteomic strategies for identification of novel targets and ...
Martin S. Tallman, D. Gary Gilliland
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Acute Leukemia in Children [PDF]
BioMed Research International, 2015 Acute lymphoblastic leukemia (ALL) is the most common cancer during childhood. Nevertheless, in recent years there have been marked improvements in treatment and consequent survival. There are a number of patients that experience relapses and patients that cannot be cured. In this special issue different aspects relating to factors influencing the best
Juan Manuel Mejía-Aranguré +1 more
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Chinese Medical Journal, 2023 Abstract Ferroptosis is an iron-dependent cell death pathway that is different from apoptosis, pyroptosis, and necrosis. The main characteristics of ferroptosis are the Fenton reaction mediated by intracellular free divalent iron ions, lipid peroxidation of cell membrane lipids, and inhibition of the anti-lipid peroxidation ...
Tianxin Lyu +4 more
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Translational Oncology, 2022 Cytokine Receptor-Like Factor 2 (CRLF2) overexpression occurs in 5-15% of B-cell precursor acute lymphoblastic leukaemia (B-ALL). In ∼50% of these cases, the mechanisms underlying this dysregulation are unknown.
Ana Luiza Tardem Maciel +12 more
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Hematology, Transfusion and Cell Therapy, 2021 Introduction: KMT2A (MLL) gene rearrangements (KMT2A -r) are associated with diverse acute leukemias. Given the high number of KMT2A fusions, screening methods guide their detection regardless of partner gene.
BA Lopes +8 more
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