Results 11 to 20 of about 1,893,034 (314)
Understanding Quality of Life in Patients With Acute Leukemia, a Global Survey
Journal of Patient-Centered Research and Reviews, 2023 Purpose: The Acute Leukemia Advocates Network (ALAN) sought to determine which factors are most associated with poor quality of life (QoL) in patients with acute leukemia and to determine key issues and unmet needs through administration of an online ...
Zack Pemberton-Whiteley +9 more
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Socioeconomic cost of AML in Sweden—A population‐based study using multiple nation‐wide registers
eJHaem, 2021 Acute myeloid leukemia (AML) is associated with a high economic and clinical burden. Recently novel therapies have been added to standard treatment regimens. Here, we evaluated the economic impact of AML up until the introduction of these novel therapies.
Emma Hernlund +6 more
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Expression of the apelinergic system and its influence on functional properties of tumor cells
Genetics & Applications, 2021 mall peptide Apelin and its cognate receptor APJ, are known to play a role in tumor angiogenesis and overall cancer progession. Certain authors suggest that the Apelin receptor is also a factor in cancer immunotherapy.
Zoran Knezevic +5 more
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Preserved cellular immunity in smoldering acute leukemia [PDF]
, 1976 "Smoldering acute leukemia", a variant of acute myelogenous leukemia, has been recognized with frequent incidence in recent years. This is chracterized by benign clinical course, poor physical findings, leukopenia and mild anemia in the ...
Hironobu Toki, Toki, Hironobu
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Identification of cooperating genetic events in acute leukemia [PDF]
, 2009 The genetic alterations associated with acute leukemia can be divided into two functional groups. The class I mutations enhance cellular proliferation and survival by constitutive activation of mainly protein tyrosine kinases signaling pathways.
Liu, Ting
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Targeting the MLL complex in acute leukemia [PDF]
, 2014 Chromosomal rearrangements leading mostly to fusion oncoproteins of the Mixed Lineage Leukemia (MLL) gene occur in about 10% of all patients with acute leukemia and are often associated with poor clinical outcome, emphasizing the need for new treatment ...
Méreau, Hélène
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Translational Oncology, 2022 Cytokine Receptor-Like Factor 2 (CRLF2) overexpression occurs in 5-15% of B-cell precursor acute lymphoblastic leukaemia (B-ALL). In ∼50% of these cases, the mechanisms underlying this dysregulation are unknown.
Ana Luiza Tardem Maciel +12 more
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Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in Acute Myeloid Leukemia [PDF]
, 2009 Background Translocations of the Mixed Lineage Leukemia (MLL) gene occur in a subset (5%) of acute myeloid leukemias (AML), and in mixed phenotype acute leukemias in infancy - a disease with extremely poor prognosis.
Meyer, Claus +26 more
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Hematology, Transfusion and Cell Therapy, 2021 Introduction: KMT2A (MLL) gene rearrangements (KMT2A -r) are associated with diverse acute leukemias. Given the high number of KMT2A fusions, screening methods guide their detection regardless of partner gene.
BA Lopes +8 more
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Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptides [PDF]
, 2012 In acute promyelocytic leukemia (APL), hematopoietic differentiation is blocked and immature blasts accumulate in the bone marrow and blood. APL is associated with chromosomal aberrations, including t(15;17) and t(11;17).
Sabine Beez (123610) +8 more
core +1 more source