Results 181 to 190 of about 310,818 (241)
Chemistry &Biodiversity, Accepted Article.Ziziphus budhensis is a species described in 2015 in Nepal poorly studied for its phytochemical composition and possible bioactivities. In this study, six extracts were obtained from Z. budhensis leaves using ultrasound assisted extraction with solvents in increasing polarity.
Samjhana Bharati +7 more
wiley +1 more source
Promising Prodiginins Biological Activities
Chemistry &Biodiversity, EarlyView.ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto +6 more
wiley +1 more source
Chemistry &Biodiversity, EarlyView.ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves +3 more
wiley +1 more source
Methods for Controlling Small GTPase Activity
ChemBioChem, Accepted Article.Small GTPases comprise a diverse class of signaling proteins in mammalian cells and regulate a variety of cellular processes such as cell growth, cell movement, vesicle formation, and nuclear transport. Due to their involvement in critical cellular pathways, changes in the activation state of small GTPases due to genetic mutations or alterations in ...
Benjamin Faulkner +3 more
wiley +1 more source
ChemBioChem, Accepted Article.Nucleophosmin 1(NPM1) is an abundant human protein endowed with many functions whose dysregulation leads to various cancers and mutations are relevant in Acute Myeloid Leukemia (AML). In the wild type form, pentameric NPM1 resides mainly in the nucleolus even if it shuttles toward the cytosol exerting its chaperon function, conversely in AML‐mutated ...
Daniele Florio +7 more
wiley +1 more source
ChemBioChem, EarlyView.Benzoylurea scaffolds accurately mimic the side‐chain vectors of the i, i + 1/2, and i + 3 positions of polyproline type II helices, showing functional activity in the disruption of a protein–protein interaction implicated in breast cancer. Given the essential role of protein–protein interactions (PPIs) in cellular signaling pathways, their selective ...
James Luccarelli +4 more
wiley +1 more source
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Background Myeloproliferative neoplasms (MPN) are associated with an increased cardiovascular risk including acute coronary syndrome. However, there is a lack of comprehensive data regarding the rate of percutaneous coronary intervention (PCI), as well as the in‐hospital characteristics and outcomes for MPN patients.
Song Peng Ang +8 more
wiley +1 more source
Mitochondria‐Catalyzed Activation of Anticancer Prodrugs
ChemCatChem, EarlyView.Prodrug C is a water soluble, monomeric compound accumulating in mitochondria of cancer cells, where it is activated in the reaction with mitochondrial H2O2. The activation leads to the release of camptothecin that causes cell cycle arrest in G2 phase and cancer cell death.
Michael Raucheisen +7 more
wiley +1 more source
Contemporary Perspectives on Chronic Renal Disorders
Chronic Diseases and Translational Medicine, Volume 11, Issue 2, Page 89-104, June 2025.ABSTRACT The prevalence of renal diseases and its associated burden on healthcare have tremendously risen in the past few years. From simple markers assessing kidney function, current renal research delves into understanding the diseases at the cellular and molecular levels and not just at treating, but at improving quality of life, arresting ...
Deenadhayalan Ashok +5 more
wiley +1 more source