Results 11 to 20 of about 420,896 (315)
Endoreduplication in Acute Leukemia [PDF]
Blood, 1963 Abstract Chromosome studies were carried out on two occasions during the evolution of a case of acute myeloblastic leukemia. A normal karyotype was detected before treatment was started. A second analysis made while the patient was under treatment with 6-mercaptopurine showed a modal number of 44 chromosomes plus a small fragment.
Cássio Bottura, Íris Ferrari
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Acute Promyelocytic Leukemia [PDF]
Cancers, 2020 Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) cytogenetically characterized by a balanced reciprocal translocation between chromosomes 15 and 17, which results in the fusion between the promyelocytic leukemia (PML) gene and retinoic acid receptor-α (RARα) [...]
Xavier Thomas, Maël Heiblig
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Focus on acute leukemias [PDF]
Cancer Cell, 2002 Progress toward cure of acute leukemia is likely to occur with new therapies directed at specific molecular targets, such as BCR/ABL, FLT3, RAS, and the NCor/HDAC complex. This goal may be facilitated by modern genomic approaches to acute leukemia, including use of DNA microarray and proteomic strategies for identification of novel targets and ...
Martin S. Tallman, D. Gary Gilliland
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Acute Leukemia in Children [PDF]
BioMed Research International, 2015 Acute lymphoblastic leukemia (ALL) is the most common cancer during childhood. Nevertheless, in recent years there have been marked improvements in treatment and consequent survival. There are a number of patients that experience relapses and patients that cannot be cured. In this special issue different aspects relating to factors influencing the best
Juan Manuel Mejía-Aranguré +1 more
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Chinese Medical Journal, 2023 Abstract Ferroptosis is an iron-dependent cell death pathway that is different from apoptosis, pyroptosis, and necrosis. The main characteristics of ferroptosis are the Fenton reaction mediated by intracellular free divalent iron ions, lipid peroxidation of cell membrane lipids, and inhibition of the anti-lipid peroxidation ...
Tianxin Lyu +4 more
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Acute Myeloid Leukemia and Acute Promyelocytic Leukemia
Hematology, 2003 AbstractThe therapeutic approach to the patient with acute myeloid leukemia (AML) currently evolves toward new frontiers. This is particularly apparent from the entree of high-throughput diagnostic technologies and the identification of prognostic and therapeutic targets, the introduction of therapies in genetically defined subgroups of AML, as well as
Martin S. Tallman +2 more
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Haematologica, 2020 Deletion 5q or monosomy 5 (-5/5q-) in acute myeloid leukemia (AML) is a common high-risk feature that is referred to allogeneic stem cell transplantation.
Xavier Poiré +15 more
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Women's Health, 2010 The treatment and survival outcome of acute leukemia in women is generally similar to that of men. However, acute leukemia in women poses additional challenges in clinical practice. In addition to important precautions during therapy, such as prevention of abnormal uterine bleeding in premenopausal women and therapy during pregnancy, women who are ...
LO COCO, FRANCESCO +2 more
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Journal of Hematology & Oncology, 2017 Background Acute myeloid leukaemia (AML) with 17p abnormalities (abn(17p)) carries a very poor prognosis due to high refractoriness to conventional chemotherapy, and allogeneic stem cell transplantation (allo-SCT) appears as the only potential curative ...
Xavier Poiré +15 more
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Haematologica, 2018 Intermediate-risk cytogenetic acute myeloid leukemia with an internal tandem duplication of FLT3 (FLT3-ITD) is associated with a high risk of relapse, and is now a standard indication for allogeneic stem cell transplantation.
Xavier Poiré +17 more
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