Results 191 to 200 of about 742,291 (311)

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Leveraging the heterogeneity of the NK cell repertoire for the development of immunotherapies for acute leukemia. [PDF]

J Transl Med
Ferron E, Jullien M, Gagne K, Retière C.   +3 more
europepmc   +1 more source

Factors Contributing to the Impairment of Growth in Children with Acute Lymphoblastic Leukemia

, 1988
K.A. Logghe, J P Bourguignon, Margarita Craen, Yves Benoît   +3 more
openalex   +2 more sources

DNA Damage Sensing and TP53 Function as Modulators of Sensitivity to Calicheamicin-Based Antibody-Drug Conjugates for Acute Leukemia. [PDF]

Cancers (Basel)
Pettenger-Willey CM, Laszlo GS, Gang M, Cole FM, Godwin CD, Erraiss S, Chanana P, Kehret AR, Li J, Barton JW, Yochim MM, Rodríguez-Arbolí E, Walter RB.   +12 more
europepmc   +1 more source

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

Geographic and Socioeconomic Determinants of Treatment Abandonment in Pediatric Acute Leukemia: A Cohort Study in South-Central Mexico. [PDF]

Cancer Control
Núñez-Enriquez JC, Luna-Silva NC, Jacuinde-Trejo K, Flores-Lujano J, Medina-León D, Alarcón-Ruiz E, Garrido-Hernández MÁ, Cruz-Medina CS, Tinoco-Montejano D, Baños-Lara MDR, Campo-Martínez MLÁD, Duarte-Rodríguez DA, Allende-López A, Casique-Aguirre D, Elizarrarás-Rivas J, Olvera-Caraza D, Solís-Poblano JC, Terán-Cerqueda V, Ramírez-Ramírez D, Huerta-Moreno A, Aristil-Chery PM, Romo-Rodríguez R, Alvarez-Rodríguez E, Lien-Chang LEJ, Zamora-Herrera G, Hidalgo BG, Herrera-Olivares W, Ruíz-Arguelles GJ, Gallardo-Pérez MM, Chávez-Aguilar LA, Márquez-Toledo A, Cano-Cuapio LS, Ramos RH, Martínez-Martell MA, Ramirez-Ramirez AB, Brindis NR, Montiel-Jarquín AJ, Galván-Díaz CA, Velasco-Hidalgo L, Medina-Sanson A, Gutiérrez-Rivera ML, Cárdenas-Conejo A, Morales-Maravilla A, Victorio-García NP, Bekker-Méndez VC, Romero-Tlalolini MLÁ, Rodríguez-Espinosa JC, Mata-Rocha M, Olivares-Sosa AI, Rosas-Vargas H, Jiménez-Morales S, Martínez MEJ, Cárdenas-González M, Mejía-Aranguré JM, López-Aguilar E, Zapata-Tarrés M, Pelayo R.   +56 more
europepmc   +1 more source

Impact of ABO incompatibility on patients’ outcome after haploidentical hematopoietic stem cell transplantation for acute myeloid leukemia - a report from the Acute Leukemia Working Party of the EBMT [PDF]

, 2017
Jonathan Canaani, Bipin N. Savani, Myriam Labopin, Xiao‐Jun Huang, Fabio Ciceri, William Arcese, Johanna Tischer, Yener Koç, Benedetto Bruno, Zafer Gülbaş, Didier Blaise, Johan Maertens, Gerhard Ehninger, Mohamad Mohty, Arnon Nagler   +14 more
openalex   +1 more source

Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis‐Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish

Advanced Science, EarlyView.
Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi, FuMing Lai, Zheng Shen, XiaoYan Zhang, HanFei Wang, WenYe Liu, YunLong Wang, KuanYu Li, GuoLiang Li, YaPing Fang, Jing‐Xia Liu   +10 more
wiley   +1 more source

A case report of mixed-phenotype acute leukemia with atypical BCR::ABL1 e13a3 fusion gene. [PDF]

Medicine (Baltimore)
Zhou Y, Liu M, Zhao Y, Zhang R, Guo Q, Wang Z, Nie Y, Yang J, Shi M.   +8 more
europepmc   +1 more source

PDIA3 Inhibition Facilitates Sensitivity of IKE‐Induced Ferroptosis via STAT3/LCN2 Axis to Improve Glioblastoma Therapy

Advanced Science, EarlyView.
In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang, Wei Wang, Xin Liu, Peifen Lu, Xinjing Liu, Qiucheng Nie, Siyuan Xin, Hong Li, Donglin Yu, Xinyue Zhang, Kailong Li, Xiaomin Han, Shuping Zhang, Wei Chong, Lili Sun, Wei Li, Tao Xin, Jin Jiao, Qiang Ma, Yiju Wei   +19 more
wiley   +1 more source