Results 191 to 200 of about 310,818 (241)
ChemElectroChem, EarlyView.This review explores the transformative role of graphene derivatives in electrochemical biosensors for diagnostics, environmental monitoring, and industrial sensing. Highlighting innovations in synthesis and covalent functionalization, it discusses how these materials enhance biosensor stability, specificity, and scalability.
Petr Jakubec +8 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.We present new BRD9‐targeting degraders featuring a chemical warhead and E3 ligase ligand that distinctly differ from the typical chemical units used for BRD9 degradation. Specifically, we identified two VHL‐based PROTACs (2 and 9) based on a [1,2,4]triazolo[4,3‐a]quinoxaline scaffold that effectively and selectively degrade BRD9 and exhibit ...
Martina Pierri +15 more
wiley +1 more source
Recent Cutting‐Edge Technologies for the Delivery of Peptide Nucleic Acid
Chemistry – A European Journal, EarlyView.This review provides an overview of PNA cellular delivery methods, starting with traditional peptide‐based systems and progressing to advanced approaches using nanoparticles, liposomes, and calixarene. It highlights how these innovative strategies have opened the way for more effective and efficient PNA delivery, ultimately enhancing the potential for ...
Concetta Avitabile +4 more
wiley +1 more source
The Evolution of Fluorescein into A Potential Theranostic Tool
Chemistry – A European Journal, EarlyView.Our study successfully evolved a fluorescent imaging agent into a potent therapeutic compound. By functionalizing fluorescein, we enhanced its fluorescence and adapted it for multicomponent reactions (MCRs). We synthesized over 20 compounds across four diverse scaffolds.
Konstantinos S. Adamis +8 more
wiley +1 more source
A phase 2 study incorporating sorafenib into the chemotherapy for older adults with FLT3-mutated acute myeloid leukemia: CALGB 11001 [PDF]
, 2017 Uy, Geoffrey L., Westervelt, Peter
core +1 more source
ChemMedChem, EarlyView.ROR1 represents a promising target for the development of novel antiproliferative compounds, giving its high expression in different cancer cell lines. The present study describes the workflow leading to the design, synthesis, and characterization of a series of para‐phenylenediamine‐based compounds able to interact with the target kinase, inhibiting ...
Gerardina Smaldone +17 more
wiley +1 more source
Clinical Pharmacology in Drug Development, EarlyView.Abstract A modified controlled‐release sodium valproate formulation (VAL001, test) was compared with an approved enteric‐coated tablet formulation (Absenor, reference). Pharmacokinetics and safety/tolerability were evaluated in healthy subjects to bridge with positive efficacy results from an early‐phase patient trial of valproate in combination with ...
Nikhil Ahuja +8 more
wiley +1 more source
ChemPlusChem, EarlyView.Gold nanoparticles (AuNPs) are widely used in biomedicine, electronics, catalysis, and environmental science. Conventional synthesis relies on harsh chemicals, driving interest in eco‐friendly methods using plants, bacteria, fungi, and algae. Biomolecules like polyphenols, proteins, and fatty acids aid nanoparticle synthesis under mild conditions. This
Youfeng Yue +3 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Apixaban could be a potential treatment option for the prevention of venous thromboembolism (VTE) in children with acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LL). This analysis describes an updated two‐compartment population pharmacokinetic (PPK) model that characterizes the PK variability of apixaban in pediatric patients with ALL ...
Praneeth Jarugula +14 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.After a medicine has been tested in pivotal trials, regulators, health technology assessment (HTA) organizations, and professional societies make decisions about the patients best served by the medicine. This study assesses how the patient populations for oncology medicines (2010–2023) are defined (1) at trial, (2) regulatory submission, (3) upon ...
Milou A. Hogervorst +5 more
wiley +1 more source