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Acute Myeloid Leukemia and Acute Promyelocytic Leukemia
Hematology, 2003 AbstractThe therapeutic approach to the patient with acute myeloid leukemia (AML) currently evolves toward new frontiers. This is particularly apparent from the entree of high-throughput diagnostic technologies and the identification of prognostic and therapeutic targets, the introduction of therapies in genetically defined subgroups of AML, as well as
Martin S. Tallman +2 more
openaire +3 more sources
Genomic Classification and Prognosis in Acute Myeloid Leukemia.
New England Journal of Medicine, 2016 BACKGROUND Recent studies have provided a detailed census of genes that are mutated in acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity defines the pathophysiology of AML and informs clinical practice ...
E. Papaemmanuil +26 more
semanticscholar +1 more source
Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome). [PDF]
, 2011 We report an allelic series of eight mutations in GATA2 underlying Emberger syndrome, an autosomal dominant primary lymphedema associated with a predisposition to acute myeloid leukemia.
C Preudhomme +32 more
core +1 more source
Pre-B-cell acute lymphoblastic leukemia with bulk extramedullary disease and chromosome 22 (EWSR1) rearrangement masquerading as Ewing sarcoma [PDF]
, 2010 We report a 2-year-old female with a subcutaneous tumor who was initially misdiagnosed as suffering from Ewing sarcoma with a positive EWSR1 rearrangement and EWS/FLI1 transcript.
Jakovljević, Gordana +6 more
core +1 more source
Journal of Hematology & Oncology, 2016 Background Data comparing fully matched and mismatched-unrelated-donor (M- and mM-URD) allogeneic hematopoietic stem cell transplant (allo-SCT) following reduced intensity conditioning regimens for acute myeloid leukemia are limited.
Marie T. Rubio +15 more
doaj +1 more source
Haematologica, 2023 Pediatric acute myeloid leukemia (AML) is a highly heterogeneous disease making standardized measurable residual disease (MRD) assessment challenging. Currently, patient-specific DNA-based assays are only rarely applied for MRD assessment in pediatric ...
Margarita Maurer-Granofszky +12 more
doaj +1 more source
Quaternion-Valued Convolutional Neural Network Applied for Acute Lymphoblastic Leukemia Diagnosis [PDF]
A. Britto and K. Valdivia Delgado (Eds.): BRACIS 2021, LNAI 13074,
pp. 280-293, 2021. Springer Nature Switzerland AG 2021, 2021 The field of neural networks has seen significant advances in recent years with the development of deep and convolutional neural networks. Although many of the current works address real-valued models, recent studies reveal that neural networks with hypercomplex-valued parameters can better capture, generalize, and represent the complexity of ...
arxiv +1 more source
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.
New England Journal of Medicine, 2013 BACKGROUND Many mutations that contribute to the pathogenesis of acute myeloid leukemia (AML) are undefined. The relationships between patterns of mutations and epigenetic phenotypes are not yet clear.
T. Ley +99 more
semanticscholar +1 more source
Overcoming steroid resistance in T cell acute lymphoblastic leukemia [PDF]
, 2016 In a Perspective, Pieter Van Vlierberghe and Steven Goossens discuss Meijerink and colleagues' findings on steroid resistance in pediatric T cell acute lymphoblastic ...
Goossens, Steven +1 more
core +3 more sources
Cancer Medicine, 2019 Deferasirox is an oral iron‐chelating agent having possible antileukemia and immune modulatory effects. Few reports have evaluated deferasirox in the setting of allogeneic hematopoietic stem cell transplantation (allo‐HSCT). We investigated the impact of
Byung‐Sik Cho +14 more
doaj +1 more source