Results 31 to 40 of about 3,163,010 (367)
Automated Detection of Acute Promyelocytic Leukemia in Blood Films and Bone Marrow Aspirates with Annotation-free Deep Learning [PDF]
arXiv, 2022 While optical microscopy inspection of blood films and bone marrow aspirates by a hematologist is a crucial step in establishing diagnosis of acute leukemia, especially in low-resource settings where other diagnostic modalities might not be available, the task remains time-consuming and prone to human inconsistencies.
arxiv
Journal of Hematology & Oncology, 2017 Background Acute myeloid leukaemia (AML) with 17p abnormalities (abn(17p)) carries a very poor prognosis due to high refractoriness to conventional chemotherapy, and allogeneic stem cell transplantation (allo-SCT) appears as the only potential curative ...
Xavier Poiré +15 more
doaj +1 more source
Chimeric antigen receptor-modified T cells for acute lymphoid leukemia.
New England Journal of Medicine, 2013 Chimeric antigen receptor-modified T cells with specificity for CD19 have shown promise in the treatment of chronic lymphocytic leukemia (CLL). It remains to be established whether chimeric antigen receptor T cells have clinical activity in acute ...
S. Grupp +12 more
semanticscholar +1 more source
Automated Detection of Acute Lymphoblastic Leukemia Subtypes from Microscopic Blood Smear Images using Deep Neural Networks [PDF]
arXiv, 2022 An estimated 300,000 new cases of leukemia are diagnosed each year which is 2.8 percent of all new cancer cases and the prevalence is rising day by day. The most dangerous and deadly type of leukemia is acute lymphoblastic leukemia (ALL), which affects people of all age groups, including children and adults.
arxiv
Journal of the American Medical Association (JAMA), 2018 Importance Bacteremia causes considerable morbidity among children with acute leukemia and those undergoing hematopoietic stem cell transplantation (HSCT). There are limited data on the effect of antibiotic prophylaxis in children. Objective To determine
S. Alexander +12 more
semanticscholar +1 more source
Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia
New England Journal of Medicine, 2017 Background Blinatumomab, a bispecific monoclonal antibody construct that enables CD3‐positive T cells to recognize and eliminate CD19‐positive acute lymphoblastic leukemia (ALL) blasts, was approved for use in patients with relapsed or refractory B‐cell ...
H. Kantarjian +25 more
semanticscholar +1 more source
Haematologica, 2018 Intermediate-risk cytogenetic acute myeloid leukemia with an internal tandem duplication of FLT3 (FLT3-ITD) is associated with a high risk of relapse, and is now a standard indication for allogeneic stem cell transplantation.
Xavier Poiré +17 more
doaj +1 more source
Clonal selection and therapy resistance in acute leukemias: Mathematical modelling explains different proliferation patterns at diagnosis and relapse [PDF]
J. R. Soc Interface 11(94):20140079, 2014, 2013 Recent experimental evidence suggests that acute myeloid leukemias may originate from multiple clones of malignant cells. Nevertheless it is not known how the observed clones may differ with respect to cell properties such as proliferation and self-renewal. There are scarcely any data on how these cell properties change due to chemotherapy and relapse.
arxiv +1 more source
Women's Health, 2010 The treatment and survival outcome of acute leukemia in women is generally similar to that of men. However, acute leukemia in women poses additional challenges in clinical practice. In addition to important precautions during therapy, such as prevention of abnormal uterine bleeding in premenopausal women and therapy during pregnancy, women who are ...
LO COCO, FRANCESCO +2 more
openaire +5 more sources
Blood, 2018 Pinometostat (EPZ-5676) is a first-in-class small-molecule inhibitor of the histone methyltransferase disrupter of telomeric silencing 1-like (DOT1L).
E. Stein +20 more
semanticscholar +1 more source