Procalcitonin Identifies Cell Injury, Not Bacterial Infection, in Acute Liver Failure. [PDF]
PLoS ONE, 2015 Because acute liver failure (ALF) patients share many clinical features with severe sepsis and septic shock, identifying bacterial infection clinically in ALF patients is challenging.
Jody A Rule +6 more
doaj +6 more sources
Circulating microRNAs Reveal Time Course of Organ Injury in a Porcine Model of Acetaminophen-Induced Acute Liver Failure. [PDF]
PLoS ONE, 2015 Acute liver failure is a rare but catastrophic condition which can progress rapidly to multi-organ failure. Studies investigating the onset of individual organ injury such as the liver, kidneys and brain during the evolution of acute liver failure, are ...
Luisa A Baker +9 more
doaj +11 more sources
Hypothermia in Acute Liver Failure [PDF]
Metabolic Brain Disease, 2004 The development of encephalopathy in patients with acute liver injury defines the occurrence of liver failure. The encephalopathy of acute liver failure is characterized by brain edema which manifests clinically as increased intracranial pressure. Despite the best available medical therapies a significant proportion of patients with acute liver failure
Jalan, Rajiv, Rose, Christopher
openaire +6 more sources
Metabolic investigations prevent liver transplantation in two young children with citrullinemia type I [PDF]
, 2010 Acute liver failure may be caused by a variety of disorders including inborn errors of metabolism. In those cases, rapid metabolic investigations and adequate treatment may avoid the need for liver transplantation.
A Dhawan +23 more
core +11 more sources
Loss of noradrenaline transporter sites in frontal cortex of rats with acute (ischemic) liver failure [PDF]
, 2001 There is increasing evidence that central noradrenaline (NA) transport mechanisms are implicated in the central nervous system complications of acute liver failure.
Adrianna Michalak +2 more
openalex +3 more sources
Future directions in acute liver failure
Hepatology, 2023 Acute liver failure (ALF) describes a clinical syndrome of rapid hepatocyte injury leading to liver failure manifested by coagulopathy and encephalopathy in the absence of pre-existing cirrhosis.
R. Stravitz +7 more
semanticscholar +1 more source
Management of Acute Liver Failure: Update 2022.
Seminars in liver disease (Print), 2022 Abbreviated pathogenesis and clinical course of the acute liver failure syndrome. The pathogenesis and clinical course of the syndrome of acute liver failure (ALF) differs depending upon the etiology of the primary liver injury.
Shannan R Tujios +2 more
semanticscholar +1 more source
Predicting outcome on admission and post-admission for acetaminophen-induced acute liver failure using classification and regression tree models. [PDF]
PLoS ONE, 2015 Assessing prognosis for acetaminophen-induced acute liver failure (APAP-ALF) patients often presents significant challenges. King's College (KCC) has been validated on hospital admission, but little has been published on later phases of illness. We aimed
Jaime Lynn Speiser +3 more
doaj +1 more source
Acute-on-Chronic Liver Failure Clinical Guidelines
American Journal of Gastroenterology, 2022 In patients with cirrhosis and chronic liver disease, acute-on-chronic liver failure is emerging as a major cause of mortality. These guidelines indicate the preferred approach to the management of patients with acute-on-chronic liver failure and ...
J. Bajaj +6 more
semanticscholar +1 more source
Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure. [PDF]
PLoS ONE, 2013 Tools to predict death or spontaneous survival are necessary to inform liver transplantation (LTx) decisions in pediatric acute liver failure (PALF), but such tools are not available.
Nabil Azhar +6 more
doaj +1 more source