Results 41 to 50 of about 563,562 (310)

Effect of taurine on chronic and acute liver injury: Focus on blood and brain ammonia

Toxicology Reports, 2016
Hyperammonemia is associated with chronic and acute liver injury. There is no promising therapeutic agent against ammonia-induced complications. Hence, finding therapeutic molecules with safe profile of administration has clinical value.
Reza Heidari, Akram Jamshidzadeh, Hossein Niknahad, Elnaz Mardani, Mohammad Mehdi Ommati, Negar Azarpira, Forouzan Khodaei, Azita Zarei, Maryam Ayarzadeh, Somayeh Mousavi, Narges Abdoli, Babak Shirazi Yeganeh, Arastoo Saeedi, Asma Najibi   +13 more
doaj   +1 more source

Small-for-size liver graft injury-impact on tumor behavior [PDF]

, 2010
The success of liver transplantation has led to an ever-increasing demand for liver grafts. Since the first successful living donor liver transplantation, this surgical innovation has been well established in children and has significantly relieved the ...
Man, K, Shih, KC
core   +1 more source

Acute Liver Injury Is Independent of B Cells or Immunoglobulin M.

PLoS ONE, 2015
Background & aimsAcute liver injury is a clinically important pathology and results in the release of Danger Associated Molecular Patterns, which initiate an immune response.
James A Richards, Martina Bucsaiova, Emily E Hesketh, Chiara Ventre, Neil C Henderson, Kenneth Simpson, Christopher O C Bellamy, Sarah E M Howie, Stephen M Anderton, Jeremy Hughes, Stephen J Wigmore   +10 more
doaj   +1 more source

Anastrozole-related acute hepatitis with autoimmune features: a case report [PDF]

, 2011
Background Two cases of acute hepatitis occurring during treatment with anastrozole have previously been reported, but the underlying mechanisms of liver injury are still uncertain.
Alessandro Inno, Michele Basso, Fabio M Vecchio, Valentina A Marsico, Eleonora Cerchiaro, Ettore D'Argento, Cinzia Bagalà, Carlo Barone   +7 more
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Risk of acute and serious liver injury associated to nimesulide and other NSAIDs: data from drug-induced liver injury case-control study in Italy [PDF]

, 2016
Aim: Drug-induced liver injury is one of the most serious adverse drug reactions and the most frequent reason for restriction of indications or withdrawal of drugs. Some nonsteroidal anti-inflammatory drugs (NSAIDs) were withdrawn from the market because
Arzenton, E., Bonaiuti, R., Bortolami, O., Capuano, A., Conforti, A., Donati, M., Lenti, M.C., Leone, R., Moretti, U., Motola, D., Rafaniello, C., Sportiello, L., Vaccheri, A., Vannacci, A.   +13 more
core   +2 more sources

Induced liver injury after high-dose methylprednisolone in a patient with multiple sclerosis [PDF]

, 2015
A 33-year-old woman with multiple sclerosis, medicated with high doses of methylprednisolone, cyclophosphamide and glatiramer acetate, was referred to our department due to acute liver injury.
Cipriano, MA, Lopes, S, Oliveira, AT, Sofia, C   +3 more
core   +1 more source

GDF8 Contributes to Liver Fibrogenesis and Concomitant Skeletal Muscle Wasting

Biomedicines, 2023
Patients with end-stage liver disease exhibit progressive skeletal muscle atrophy, highlighting a negative crosstalk between the injured liver and muscle. Our study was to determine whether TGFβ ligands function as the mediators.
Alexander Culver, Matthew Hamang, Yan Wang, Huaizhou Jiang, Jennifer Yanum, Emily White, Samer Gawrieh, Raj K. Vuppalanchi, Naga P. Chalasani, Guoli Dai, Benjamin C. Yaden   +10 more
doaj   +1 more source

Ammonia toxicity: from head to toe? [PDF]

, 2016
Ammonia is diffused and transported across all plasma membranes. This entails that hyperammonemia leads to an increase in ammonia in all organs and tissues.
Dasarathy, Srinivasan, Mookerjee, Rajeshwar P., Ott, Peter, Rackayova, Veronika, Rangroo Thrane, Vinita, Rose, Christopher, Vairappan, Balasubramaniyan   +6 more
core   +1 more source

Commensal Lactobacillus Controls Immune Tolerance during Acute Liver Injury in Mice

Cell Reports, 2017
Summary: Gut-derived microbial antigens trigger the innate immune system during acute liver injury. During recovery, regulatory immunity plays a role in suppressing inflammation; however, the precise mechanism underlying this process remains obscure ...
Nobuhiro Nakamoto, Takeru Amiya, Ryo Aoki, Nobuhito Taniki, Yuzo Koda, Kentaro Miyamoto, Toshiaki Teratani, Takahiro Suzuki, Sayako Chiba, Po-Sung Chu, Atsushi Hayashi, Akihiro Yamaguchi, Shunsuke Shiba, Rei Miyake, Tadashi Katayama, Wataru Suda, Yohei Mikami, Nobuhiko Kamada, Hirotoshi Ebinuma, Hidetsugu Saito, Masahira Hattori, Takanori Kanai   +21 more
doaj   +1 more source

ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury

Nature Communications, 2023
Mitochondria dysfunction contributes to acute liver injuries, and mitochondrial regulators, such as PGC-1α and MCJ, affect liver regeneration. Therefore, identification of mitochondrial modulators may pave the way for developing therapeutic strategies ...
Yankun Zhang, Yuchen Fan, Huili Hu, Xiaohui Zhang, Zehua Wang, Zhuanchang Wu, Liyuan Wang, Xiangguo Yu, Xiaojia Song, Peng Xiang, Xiaodong Zhang, Tixiao Wang, Siyu Tan, Chunyang Li, Lifen Gao, Xiaohong Liang, Shuijie Li, Nailin Li, Xuetian Yue, Chunhong Ma   +19 more
doaj   +1 more source