Results 191 to 200 of about 325,916 (299)

Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1‐Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation

Advanced Science, EarlyView.
Hypertrophic scar formation is driven by excessive mitochondrial fission in wound macrophages, which we discover is governed by a novel AURKB‐DRP1(Ser616) axis. The study develops a targeted therapy using cRGD‐decorated extracellular vesicles to deliver the natural compound Asiaticoside specifically to macrophages.
Luyu Li, Chenli Si, Xue Wang, Xiaojin Wu, Ying Shang, Shengfang Ge, Yong Wang, Yong Zuo, Zhen Zhang   +8 more
wiley   +1 more source

Rab43 mitigates the inflammatory response in acute lung injury via MyD88 ubiquitination. [PDF]

Sci Rep
Wang Y, Liu X, Zhu Z, Wu D, Chen Y, Gong D, Wu P, Qian H, He B, Wang G.   +9 more
europepmc   +1 more source

[Acute lung injuries].

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2003
Shu, Hashimoto, Tomoko, Kobayashi, Takashi, Horie   +2 more
openaire   +1 more source

Protection of LPS-Induced Murine Acute Lung Injury by Sphingosine-1-Phosphate Lyase Suppression

, 2010
Yutong Zhao, И. А. Горшкова, Evgeny Berdyshev, Donghong He, Panfeng Fu, Wenli Ma, Yanlin Su, Peter V. Usatyuk, Srikanth Pendyala, Babak Oskouian, Julie D. Saba, Joe G. N. Garcia, Viswanathan Natarajan   +12 more
openalex   +2 more sources

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Acute Lung Injury Induced by Hyperbaric Oxygen or Other External Factors, with a Focus on Exosomes. [PDF]

Int J Mol Sci
Shi J, Zhao H, Yan C, Zhu P, Zhu Q, Ding W, Wang L, Zhao Y, Wang Y, Fang Y.   +9 more
europepmc   +1 more source

Targeted H2S Delivery System Attenuates Blood‐Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway

Advanced Science, EarlyView.
The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen, Xinkai Pu, Ruiyang Li, Yuezhou Wu, Qirong Zhou, Jian Wang, Yuxuan Qian, Fengjie Lu, Jian‐Yuan Zhao, Zhida Su, Jiacan Su, Xiaofeng Lian   +11 more
wiley   +1 more source

The Extracellular Matrix and the Immune System in Acute Lung Injury: Partners in Damage and Repair. [PDF]

Biomedicines
Xie F, Sun Y, Wang J, Luo W, Zhang X, Cheng Y, Chao J.   +6 more
europepmc   +1 more source

Adipocyte‐Derived Exosomal miR‐5099 Mitigates M1 Macrophage Polarization and Adipose Inflammation via c‐Met/NF‐κB Axis to Improve Metabolic Health

Advanced Science, EarlyView.
Celastrol upregulates adipocyte‐derived exosomal miR‐5099, suppressing the macrophage c‐Met/NF‐κB axis to mitigate pro‐inflammatory M1 polarization and adipose inflammation. These miR‐5099‐enriched exosomes also act as endocrine signals targeting the liver, muscle, and adipocytes to significantly enhance systemic insulin sensitivity.
Ping Tang, Lixin Tai, Hongxia Xu, Dongliang Zhu, Jiajia Li, Hao Feng, Jinghui Cui, Shuhai Lin, Li‐jun Di, Li Wang   +9 more
wiley   +1 more source

Microencapsulated <i>Akkermansia muciniphila</i> alleviates acute lung injury in juvenile mice by protecting intestinal barrier. [PDF]

Front Cell Infect Microbiol
Chen Y, He Z, Shi X, Zhang J, Mao L, Lu Z, Zou Z, Chen C, Qin X, Li Y.   +9 more
europepmc   +1 more source