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Microparticles and acute lung injury
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2012The pathophysiology of acute lung injury (ALI) and its most severe form, acute respiratory distress syndrome (ARDS), is characterized by increased vascular and epithelial permeability, hypercoagulation and hypofibrinolysis, inflammation, and immune modulation.
Mark, McVey +2 more
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Seminars in Respiratory and Critical Care Medicine, 2006
Acute lung injury (ALI) is a complex syndrome involving the interplay of both environmental (such as the addition of mechanical ventilation) and genetic factors. Clinical models have identified risk factors for development and poor outcome but these strategies remain imprecise.
Carlos, Flores +4 more
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Acute lung injury (ALI) is a complex syndrome involving the interplay of both environmental (such as the addition of mechanical ventilation) and genetic factors. Clinical models have identified risk factors for development and poor outcome but these strategies remain imprecise.
Carlos, Flores +4 more
openaire +2 more sources
Aspiration and acute lung injury
International Journal of Obstetric Anesthesia, 1993Aspiration is a common clinical entity whose consequences range from the relatively benign to fulminant acute respiratory failure and death. Clinical situations in which airway protection is lost or compromised predispose patients to aspiration. Treatment of aspiration, while generally supportive, depends in part upon the material aspirated and the ...
M G, Lykens, D L, Bowton
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Sphingolipids in Acute Lung Injury
2013Acute lung injury is a life-threatening disease that is characterized by pulmonary inflammation, loss of barrier functions, and hypoxemia. Sphingolipids are critically involved in the disease process that they can both expedite and extenuate: They expedite inflammation by promoting chemotaxis (neutral sphingomyelinase), increased endothelial ...
Stefan, Uhlig, Yang, Yang
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Pathophysiology of Acute Lung Injury
Seminars in Respiratory and Critical Care Medicine, 2001The acute respiratory distress syndrome (ARDS) is a life-threatening syndrome that may occur in any patient without any predisposition and that is mostly triggered by underlying processes such as sepsis, pneumonia, trauma, multiple transfusions, and pancreatitis. ARDS is defined by (1) acute onset, (2) bilateral infiltrates in chest x-rays, (3) absence
A, Günther +3 more
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Clinics in Chest Medicine, 2016
The foundation of mechanical ventilation for acute respiratory distress syndrome involves limiting lung overdistention by using small tidal volumes or transpulmonary pressures. Potential for additional lung recruitment with higher positive end-expiratory pressure (PEEP) should be assessed.
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The foundation of mechanical ventilation for acute respiratory distress syndrome involves limiting lung overdistention by using small tidal volumes or transpulmonary pressures. Potential for additional lung recruitment with higher positive end-expiratory pressure (PEEP) should be assessed.
openaire +2 more sources
Inflammasome Activation in Acute Lung Injury.
American Journal of Physiology - Lung cellular and Molecular Physiology, 2020Inflammasomes are multi-protein complexes tasked with sensing endogenous or exogenous inflammatory signals, and integrating this signal into a downstream response.
M. McVey, B. Steinberg, N. Goldenberg
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Biomarkers in acute lung injury
Respiratory Physiology & Neurobiology, 2015Acute respiratory distress syndrome (ARDS) and its milder form acute lung injury (ALI) may result from various diseases and situations including sepsis, pneumonia, trauma, acute pancreatitis, aspiration of gastric contents, near-drowning etc. ALI/ARDS is characterized by diffuse alveolar injury, lung edema formation, neutrophil-derived inflammation ...
Daniela, Mokra, Petra, Kosutova
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Mechanisms of acute lung injury
Current Opinion in Critical Care, 1997Acute lung injury is the end result of common pathways initiated by a variety of local or systemic insults leading to diffuse damage to the pulmonary parenchyma. Despite the accumulation of abundant information regarding the physiological and cellular basis of lung injury and increasingly sophisticated intensive care, an improvement in prognosis has ...
G P, Downey, J T, Granton
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Neutrophils and acute lung injury
Critical Care Medicine, 2003Neutrophils are an important component of the inflammatory response that characterizes acute lung injury (ALI). This discussion aims to review the contribution of neutrophils to the development and progression of ALI and to highlight the major intracellular signaling pathways that are involved in neutrophil activation in the setting of ALI.MEDLINE ...
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