Results 51 to 60 of about 541,112 (308)

A fresh look at paralytics in the critically ill: real promise and real concern. [PDF]

, 2012
Neuromuscular blocking agents (NMBAs), or "paralytics," often are deployed in the sickest patients in the intensive care unit (ICU) when usual care fails.
Kenyon, Nicholas J, Price, David, Stollenwerk, Nicholas   +2 more
core   +2 more sources

AM966, an Antagonist of Lysophosphatidic Acid Receptor 1, Increases Lung Microvascular Endothelial Permeability through Activation of Rho Signaling Pathway and Phosphorylation of VE-Cadherin

Mediators of Inflammation, 2017
Maintenance of pulmonary endothelial barrier integrity is important for reducing severity of lung injury. Lysophosphatidic acid (LPA) regulates cell motility, cytoskeletal rearrangement, and cell growth.
Junting Cai, Jianxin Wei, Shuang Li, Tomeka Suber, Jing Zhao   +4 more
doaj   +1 more source

Viral pathogens and acute lung injury: investigations inspired by the SARS epidemic and the 2009 H1N1 influenza pandemic. [PDF]

, 2013
Acute viral pneumonia is an important cause of acute lung injury (ALI), although not enough is known about the exact incidence of viral infection in ALI.
Hendrickson, Carolyn M, Matthay, Michael A   +1 more
core   +2 more sources

A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry

Nature Communications, 2021
The serine protease TMPRSS2 primes SARS-CoV-2 glycoprotein for cell entry. Here, the authors perform a screen to identify drugs that reduce TMPRSS2 expression and find that halofuginone modulates proteasome-mediated degradation of TMPRSS2 and reduces ...
Yanwen Chen, Travis B. Lear, John W. Evankovich, Mads B. Larsen, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Laura Salminen, Daniel P. Camarco, Karina C. Lockwood, Ferhan Tuncer, Jie Liu, Michael M. Myerburg, John F. McDyer, Yuan Liu, Toren Finkel, Bill B. Chen   +16 more
doaj   +1 more source

Hyperoxia and acute lung injury

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2008
to the editor: The review by Matute-Bello et al. ([15][1]) has misleading and potentially dangerous statements concerning the role of hyperoxia in human acute lung injury (ALI). Table 4 states “in normal human lungs, 100% oxygen has not induced lung injury … ” The text states that ...
Aron B, Fisher, Michael F, Beers
openaire   +3 more sources

Physiological effects of high-flow oxygen via endotracheal tube versus T-piece strategies during spontaneous breathing trials: a study protocol and statistical analysis for a single-centre randomised crossover study

BMJ Open
Introduction The optimal method for conducting spontaneous breathing trials (SBTs) remains a subject of ongoing debate. High-flow oxygen via endotracheal tube (HFOT) has emerged as a novel alternative for SBTs.
Jian-Xin Zhou, Hong-Liang Li, Ming-Yue Miao, Shan-Shan Xu, Rui-Zhi Zhang, Xu An, Yue-Fu Wang   +6 more
doaj   +1 more source

Macrophage-expressed IFN-β contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia [PDF]

, 2013
Influenza viruses (IV) cause pneumonia in humans with progression to lung failure and fatal outcome. Dysregulated release of cytokines including type I interferons (IFNs) has been attributed a crucial role in immune-mediated pulmonary injury during ...
Bodner, Johannes, Gattenlöhner, Stefan, Gruber, Achim D., Herold, Susanne, Högner, Katrin, Kalinke, Ulrich, Lewe-Schlosser, Peter, Lohmeyer, Juergen, Matrosovich, Mikhail, Pleschka, Stephan, Plog, Stephanie, Seeger, Werner, Walmrath, Hans-Dieter, Wolff, Thorsten   +13 more
core   +4 more sources

Silencing airway epithelial cell-derived hepcidin exacerbates sepsis-induced acute lung injury [PDF]

, 2014
INTRODUCTION: The production of antimicrobial peptides by airway epithelial cells is an important component of the innate immune response to pulmonary infection and inflammation. Hepcidin is a β-defensin-like antimicrobial peptide and acts as a principal
Cong Li Zeng, Jun Lu Wang, Qi Xing Chen, Qing Hua Chen, Sheng Wen Song, Xia Zheng, Xiang Ming Fang   +6 more
core   +1 more source

Hyperoxic Acute Lung Injury [PDF]

Respiratory Care, 2013
Prolonged breathing of very high F(IO(2)) (F(IO(2)) ≥ 0.9) uniformly causes severe hyperoxic acute lung injury (HALI) and, without a reduction of F(IO(2)), is usually fatal. The severity of HALI is directly proportional to P(O(2)) (particularly above 450 mm Hg, or an F(IO(2)) of 0.6) and exposure duration.
Kallet, Richard H, Matthay, Michael A
openaire   +4 more sources

protection by adrenomedullin [PDF]

, 2014
Ventilator-induced lung injury (VILI) contributes to morbidity and mortality in acute respiratory distress syndrome (ARDS). Particularly pre-injured lungs are susceptible to VILI despite protective ventilation. In a previous study, the endogenous peptide
Gruber, Achim Dieter, Hellwig, Katherina, Hippenstiel, Stefan, Kershaw, Olivia, Kummer, Wolfgang, Menger, Michael D., Müller-Redetzky, Holger C, Paddenberg, Renate, Pfeil, Uwe, Suttorp, Norbert, Tschernig, Thomas, Weissmann, Norbert, Will, Daniel, Witzenrath, Martin   +13 more
core   +1 more source