Results 41 to 50 of about 318,103 (313)
, 2018 A wide variety of insults can produce acute lung damage, inclusive of those that injure the lungs directly. The clinical syndrome of acute onset respiratory distress, dyspnea, and bilateral infiltrates is referred to as acute respiratory distress syndrome.
Cheung O. -Y., Graziano P., Smith M. L.
openaire +2 more sources
Internal Medicine, 2009 The first report of acute respiratory distress syndrome (ARDS) was published in 1967, and even now acute lung injury (ALI) and ARDS are severe forms of diffuse lung disease that impose a substantial health burden all over the world. Recent estimates indicate approximately 190,000 cases per year of ALI in the United States each year, with an associated ...
Tsushima, Kenji +5 more
openaire +3 more sources
Macrolides for Acute Lung Injury [PDF]
Chest, 2012 In this issue of CHEST (see page 1153), Walkey and Wiener1 examine the association between receipt of a macrolide antibiotic and mortality in patients with acute lung injury (ALI). The authors used existing, publicly available data from the Acute Respiratory Distress Network (ARDSNet) Lisofylline and Respiratory Management of Acute Lung Injury (LARMA ...
Michael J, Noto, Arthur P, Wheeler
openaire +2 more sources
Biomarkers in acute lung injury [PDF]
Translational Research, 2012 Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) result in high permeability pulmonary edema causing hypoxic respiratory failure with high morbidity and mortality. As the population ages, the incidence of ALI is expected to rise. Over the last decade, several studies have identified biomarkers in plasma and bronchoalveolar lavage ...
Maneesh, Bhargava, Chris H, Wendt
openaire +2 more sources
CXCR2 in Acute Lung Injury [PDF]
Mediators of Inflammation, 2012 In pulmonary inflammation, recruitment of circulating polymorphonuclear leukocytes is essential for host defense and initiates the following specific immune response. One pathological hallmark of acute lung injury and acute respiratory distress syndrome is the uncontrolled transmigration of neutrophils into the lung interstitium and alveolar space ...
Konrad, Franziska Magdalena +1 more
openaire +4 more sources
Mediators of Inflammation, 2017 Maintenance of pulmonary endothelial barrier integrity is important for reducing severity of lung injury. Lysophosphatidic acid (LPA) regulates cell motility, cytoskeletal rearrangement, and cell growth.
Junting Cai +4 more
doaj +1 more source
Nature Medicine, 2012 Bone marrow–derived stromal cells (BMSCs) protect against acute lung injury (ALI). To determine the role of BMSC mitochondria in this protection, we airway-instilled mice first with lipopolysaccharide (LPS) and then with either mouse BMSCs (mBMSCs) or ...
M. Islam +9 more
semanticscholar +1 more source
Nature Communications, 2021 The serine protease TMPRSS2 primes SARS-CoV-2 glycoprotein for cell entry. Here, the authors perform a screen to identify drugs that reduce TMPRSS2 expression and find that halofuginone modulates proteasome-mediated degradation of TMPRSS2 and reduces ...
Yanwen Chen +16 more
doaj +1 more source
Hyperoxia and acute lung injury
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2008 to the editor: The review by Matute-Bello et al. ([15][1]) has misleading and potentially dangerous statements concerning the role of hyperoxia in human acute lung injury (ALI). Table 4 states “in normal human lungs, 100% oxygen has not induced lung injury … ” The text states that ...
Aron B, Fisher, Michael F, Beers
openaire +3 more sources
BMJ OpenIntroduction The optimal method for conducting spontaneous breathing trials (SBTs) remains a subject of ongoing debate. High-flow oxygen via endotracheal tube (HFOT) has emerged as a novel alternative for SBTs.
Jian-Xin Zhou +6 more
doaj +1 more source