Results 31 to 40 of about 317,931 (266)
Cell Reports, 2014 Summary: Acute lung injury (ALI) is linked to mitochondrial injury, resulting in impaired cellular oxygen utilization; however, it is unknown how these events are linked on the molecular level. Cardiolipin, a mitochondrial-specific lipid, is generated by
Bill B. Chen +19 more
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The role of ubiquitination and deubiquitination in the regulation of cell junctions
Protein & Cell, 2017 Maintenance of cell junctions plays a crucial role in the regulation of cellular functions including cell proliferation, permeability, and cell death.
Junting Cai +3 more
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, 2018 A wide variety of insults can produce acute lung damage, inclusive of those that injure the lungs directly. The clinical syndrome of acute onset respiratory distress, dyspnea, and bilateral infiltrates is referred to as acute respiratory distress syndrome.
Cheung O. -Y., Graziano P., Smith M. L.
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Obesity and Acute Lung Injury [PDF]
Clinics in Chest Medicine, 2009 Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) are common indications for ICU admission and mechanical ventilation. ALI/ARDS also consumes significant health care resources and is a common cause of death in ICU patients.
Jennifer W, McCallister +2 more
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Internal Medicine, 2009 The first report of acute respiratory distress syndrome (ARDS) was published in 1967, and even now acute lung injury (ALI) and ARDS are severe forms of diffuse lung disease that impose a substantial health burden all over the world. Recent estimates indicate approximately 190,000 cases per year of ALI in the United States each year, with an associated ...
Tsushima, Kenji +5 more
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Macrolides for Acute Lung Injury [PDF]
Chest, 2012 In this issue of CHEST (see page 1153), Walkey and Wiener1 examine the association between receipt of a macrolide antibiotic and mortality in patients with acute lung injury (ALI). The authors used existing, publicly available data from the Acute Respiratory Distress Network (ARDSNet) Lisofylline and Respiratory Management of Acute Lung Injury (LARMA ...
Michael J, Noto, Arthur P, Wheeler
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Biomarkers in acute lung injury [PDF]
Translational Research, 2012 Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) result in high permeability pulmonary edema causing hypoxic respiratory failure with high morbidity and mortality. As the population ages, the incidence of ALI is expected to rise. Over the last decade, several studies have identified biomarkers in plasma and bronchoalveolar lavage ...
Maneesh, Bhargava, Chris H, Wendt
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CXCR2 in Acute Lung Injury [PDF]
Mediators of Inflammation, 2012 In pulmonary inflammation, recruitment of circulating polymorphonuclear leukocytes is essential for host defense and initiates the following specific immune response. One pathological hallmark of acute lung injury and acute respiratory distress syndrome is the uncontrolled transmigration of neutrophils into the lung interstitium and alveolar space ...
Konrad, Franziska Magdalena +1 more
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Mediators of Inflammation, 2017 Maintenance of pulmonary endothelial barrier integrity is important for reducing severity of lung injury. Lysophosphatidic acid (LPA) regulates cell motility, cytoskeletal rearrangement, and cell growth.
Junting Cai +4 more
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Nature Communications, 2021 The serine protease TMPRSS2 primes SARS-CoV-2 glycoprotein for cell entry. Here, the authors perform a screen to identify drugs that reduce TMPRSS2 expression and find that halofuginone modulates proteasome-mediated degradation of TMPRSS2 and reduces ...
Yanwen Chen +16 more
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