Results 21 to 30 of about 317,931 (266)

Destabilization of Lysophosphatidic Acid Receptor 1 Reduces Cytokine Release and Protects Against Lung Injury

EBioMedicine, 2016
Lysophosphatidic acid receptor 1 (LPA1) is a druggable target for treating pulmonary inflammatory diseases. However, the molecular regulation of LPA1 stability, a factor that critically impacts its biological activity, remains largely unknown.
Jing Zhao, Jianxin Wei, Su Dong, Rachel K. Bowser, Lina Zhang, Anastasia M. Jacko, Yutong Zhao   +6 more
doaj   +1 more source

Imaging of Acute Lung Injury [PDF]

Radiologic Clinics of North America, 2016
Acute lung injury (ALI) is the clinical syndrome associated with histopathologic diffuse alveolar damage. It is a common cause of acute respiratory symptoms and admission to the intensive care unit. Diagnosis of ALI is typically based on clinical and radiographic criteria; however, because these criteria can be nonspecific, diagnostic uncertainty is ...
Elicker, Brett M, Jones, Kirk T, Naeger, David M, Frank, James A   +3 more
openaire   +4 more sources

A Repurposed Drug Screen for Compounds Regulating Aquaporin 5 Stability in Lung Epithelial Cells

Frontiers in Pharmacology, 2022
Aquaporin 5 (AQP5) is expressed in several cell types in the lung and regulates water transport, which contributes to barrier function during injury and the composition of glandular secretions.
John Villandre, John Villandre, Virginia White, Travis B. Lear, Travis B. Lear, Yanwen Chen, Ferhan Tuncer, Emily Vaiz, Beyza Tuncer, Karina Lockwood, Dan Camarco, Yuan Liu, Yuan Liu, Yuan Liu, Bill B. Chen, Bill B. Chen, Bill B. Chen, John Evankovich, John Evankovich   +18 more
doaj   +1 more source

Research progress on the mechanism of ferroptosis in neonatal acute lung injury [PDF]

Jichu yixue yu linchuang, 2023
Acute lung injury is a common critical illness in neonates. Ferroptosis, a novel form of programmed cell death, plays an important role in the process of acute lung injury by regulating iron homeostasis, metabolism of amino acid and lipid peroxidation ...
CHU Xiaoyun, CAI Cheng
doaj   +1 more source

RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity

eLife, 2016
Toll-like receptor 2 (TLR2) is a pattern recognition receptor that recognizes many types of PAMPs that originate from gram-positive bacteria. Here we describe a novel mechanism regulating TLR2 protein expression and subsequent cytokine release through ...
Alison C McKelvey, Travis B Lear, Sarah R Dunn, John Evankovich, James D Londino, Joseph S Bednash, Yingze Zhang, Bryan J McVerry, Yuan Liu, Bill B Chen   +9 more
doaj   +1 more source

Use of airway pressure-based indices to detect high and low inspiratory effort during pressure support ventilation: a diagnostic accuracy study

Annals of Intensive Care, 2023
Background Assessment of the patient’s respiratory effort is essential during assisted ventilation. We aimed to evaluate the accuracy of airway pressure (P aw)-based indices to detect potential injurious inspiratory effort during pressure support (PS ...
Yan-Lin Yang, Yang Liu, Ran Gao, De-Jing Song, Yi-Min Zhou, Ming-Yue Miao, Wei Chen, Shu-Peng Wang, Yue-Fu Wang, Linlin Zhang, Jian-Xin Zhou   +10 more
doaj   +1 more source

Glycolysis and acute lung injury: A review

Asian Pacific Journal of Tropical Medicine, 2023
Acute lung injury is featured as diffuse pulmonary edema and persistent hypoxemia caused by lung or systemic injury. It is believed that these pathological changes are associated with damage to the alveolar epithelium and vascular endothelium ...
Yang Yi, Jun Chen, Nan Li, Yue Huang, Jichao Peng, Xiaoran Liu   +5 more
doaj   +1 more source

Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity

Nature Communications, 2017
How NALP7 inflammasome formation is regulated is unclear. Here the authors show that STAMBP prevents lysosomal degradation of NALP7 and present BC-1471 as a potential therapeutic STAMBP inhibitor, showing it can reduce TLR-induced IL-1β production.
Joseph S. Bednash, Nathaniel Weathington, James Londino, Mauricio Rojas, Dexter L. Gulick, Robert Fort, SeungHye Han, Alison C. McKelvey, Bill B. Chen, Rama K. Mallampalli   +9 more
doaj   +1 more source

Immunotherapy strategies and prospects for acute lung injury: Focus on immune cells and cytokines

Frontiers in Pharmacology, 2022
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a disastrous condition, which can be caused by a wide range of diseases, such as pneumonia, sepsis, traumas, and the most recent, COVID-19.
Wenfang Zhu, Yiwen Zhang, Yinghong Wang
doaj   +1 more source

The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor

Journal of Immunology Research, 2015
Interleukin- (IL-) 22 signaling is protective in animal models of pneumonia and bacteremia by Klebsiella pneumoniae and mediates tissue recovery from influenza and Staph aureus infection.
Joseph Franz, Jacob Jerome, Travis Lear, Qiaoke Gong, Nathaniel M. Weathington   +4 more
doaj   +1 more source