Results 21 to 30 of about 3,455,272 (209)

Factor H preserves alternative complement function during ARDS, linked to improved survival

ERJ Open Research, 2023
Background Effective regulation of complement activation may be crucial to preserving complement function during acute respiratory distress syndrome (ARDS). Factor H is the primary negative regulator of the alternative pathway of complement.
William Bain, Mohammadreza Tabary, Sara R. Moore, Xiaojing An, Georgios D. Kitsios, Bryan J. McVerry, Prabir Ray, Anuradha Ray, Rama K. Mallampalli, Viviana P. Ferreira, Janet S. Lee, S. Mehdi Nouraie   +11 more
doaj   +1 more source

Research Progress of Ferroptosis in Acute Lung Injury [PDF]

Zhongguo quanke yixue, 2023
Ferroptosis, a novel programmed cell death characterized by intracellular accumulation of lipid peroxides, has played an important role in a wide range of diseases. Acute lung injury is a critical illness caused by several reasons, and the mortality rate
ZHOU Sijiang, NING Zong
doaj   +1 more source

Pediatric acute lung injury [PDF]

Paediatric Respiratory Reviews, 2007
Among ventilated children, the incidence of acute lung injury (ALI) was 9%; of that latter group 80% developed the acute respiratory distress syndrome (ARDS). The population-based prevalence of pediatric ARDS was 5.5 cases/100.000 inhabitants.
P, Dahlem, W M C, van Aalderen, A P, Bos
openaire   +2 more sources

Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases

Frontiers in Immunology, 2021
The IL-36 family of cytokines were identified in the early 2000’s as a new subfamily of the IL-1 cytokine family, and since then, the role of IL-36 cytokines during various inflammatory processes has been characterized.
Hernán F. Peñaloza, Rick van der Geest, Joel A. Ybe, Theodore J. Standiford, Janet S. Lee, Janet S. Lee   +5 more
doaj   +1 more source

Imaging of Acute Lung Injury [PDF]

Radiologic Clinics of North America, 2016
Acute lung injury (ALI) is the clinical syndrome associated with histopathologic diffuse alveolar damage. It is a common cause of acute respiratory symptoms and admission to the intensive care unit. Diagnosis of ALI is typically based on clinical and radiographic criteria; however, because these criteria can be nonspecific, diagnostic uncertainty is ...
Elicker, Brett M, Jones, Kirk T, Naeger, David M, Frank, James A   +3 more
openaire   +4 more sources

FBXO17 promotes cell proliferation through activation of Akt in lung adenocarcinoma cells

Respiratory Research, 2018
Background The ubiquitin-proteasome pathway, mediated in part, by ubiquitin E3 ligases, is critical in regulating cellular processes such as cell proliferation, apoptosis, and migration.
Tomeka L. Suber, Ina Nikolli, Michael E. O’Brien, James Londino, Jing Zhao, Kong Chen, Rama K. Mallampalli, Yutong Zhao   +7 more
doaj   +1 more source

Phagocytosis is a primary determinant of pulmonary clearance of clinical Klebsiella pneumoniae isolates

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionKlebsiella pneumoniae (Kp) is a common cause of hospital-acquired pneumonia. Although previous studies have suggested that evasion of phagocytic uptake is a virulence determinant of Kp, few studies have examined phagocytosis sensitivity in ...
Rick van der Geest, Hongye Fan, Hernán F. Peñaloza, William G. Bain, William G. Bain, Zeyu Xiong, Naina Kohli, Emily Larson, Mara L. G. Sullivan, Jonathan M. Franks, Donna B. Stolz, Ryota Ito, Kong Chen, Yohei Doi, Yohei Doi, Melanie J. Harriff, Melanie J. Harriff, Janet S. Lee, Janet S. Lee, Janet S. Lee   +19 more
doaj   +1 more source

The Beta Agonist Lung Injury TrIal (BALTI) : prevention trial protocol [PDF]

, 2011
Background: Acute lung injury complicates approximately 25-30% of subjects undergoing oesophagectomy. Experimental studies suggest that treatment with beta agonists may prevent the development of acute lung injury by decreasing inflammatory cell ...
Matthew W Cooke, Thickett, David R, Lamb, S. E. (Sallie E.), Thickett David R, David R Thickett, Cooke, Matthew (Professor of clinical systems design), Lamb, Sarah E, Perkins, Gavin D., Daniel Park, Mistry Dipesh, Fang Gao, Gao, Fang; id_orcid, Alderson, Derek, Cooke Matthew W, Gao Fang, Dipesh Mistry, Alderson Derek, Gao, Fang, Mistry, Dipesh, Park, Daniel P., Park Daniel, Cooke, Matthew W, Thickett, David R; id_orcid, Gates, Simon, Sarah E Lamb, Park, Daniel, Gavin D Perkins, Perkins, Gavin D, Simon Gates, Thickett, David R., Smith, F. Gao (Fang Gao), Gates Simon, Lamb Sarah E, Derek Alderson, Perkins Gavin D   +34 more
core   +3 more sources

Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction (HARP-2) trial : study protocol for a randomized controlled trial [PDF]

, 2012
Acute lung injury (ALI) is a common devastating clinical syndrome characterized by life-threatening respiratory failure requiring mechanical ventilation and multiple organ failure.
O'Kane, Cecilia M., O’Kane, Cecilia M., Laffey, John G, Cross, Mark, John G Laffey, McAuley, Daniel F; id_orcid, McNally, Christine, Michael Stevenson, Perkins, Gavin D., Crealey, Grainne, Laffey, John G., Daniel F McAuley, Murphy, Lynn, HASH(0x55a67ff73468), Stevenson, Michael, Cross, L. J. Mark, Grainne Crealey, Cecilia M O’Kane, McAuley, Daniel F., Mark Cross, null null, Gavin D Perkins, Perkins, Gavin D, Christine McNally, Lynn Murphy, O'Kane, Cecilia M, Cross Mark, Stevenson Michael, Murphy Lynn, McNally Christine, Crealey Grainne, Laffey John G, O’Kane Cecilia M, McAuley Daniel F, Perkins Gavin D, McAuley, Daniel F, and the HARP-2 investigators on behalf of the Irish Critical Care Trials Group, O’Kane, Cecilia M   +37 more
core   +2 more sources

Simvastatin reduces endotoxin-induced acute lung injury by decreasing neutrophil recruitment and radical formation. [PDF]

, 2012
Treatment of acute lung injury (ALI) remains an unsolved problem in intensive care medicine. As simvastatin exerts protective effects in inflammatory diseases we explored its effects on development of ALI and due to the importance of neutrophils in ALI ...
Vijayan, Santosh, Mörgelin Matthias, Grommes Jochen, Köppel, Thomas, Grommes, Jochen, Binneboesel, Marcel, Mörgelin, Matthias, Helene Hartwig (158829), Weber, Christian, Matthias Mörgelin (109607), Rolf Dembinski, Santosh Vijayan, Jochen Grommes (158815), Söhnlein, Oliver, Dembinski, Rolf, Drechsler, Maik, Thomas Andreas Koeppel, Oliver Soehnlein, Moergelin, Matthias, Vijayan Santosh, Dembinski Rolf, Weber Christian, Santosh Vijayan (158820), Koeppel, Thomas Andreas, Binnebösel, Marcel, Christian Weber (86566), Maik Drechsler (158824), Michael Jacobs, Maik Drechsler, Lund University., Rolf Dembinski (12675), Thomas Andreas Koeppel (158847), Koeppel Thomas Andreas, Marcel Binnebösel, Matthias Mörgelin, Jacobs, Michael, Jacobs Michael, Binnebösel Marcel, Oliver Soehnlein (158864), Michael Jacobs (105163), Hartwig Helene, Jochen Grommes, Mörgelin, Matthias,, Helene Hartwig, Marcel Binnebösel (158855), Soehnlein, Oliver, Hartwig, Helene, Drechsler Maik, Soehnlein Oliver, Christian Weber   +49 more
core   +2 more sources