Results 21 to 30 of about 318,103 (313)
Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome
Acta Pharmaceutica Sinica B, 2021 The use of small interfering RNAs (siRNAs) has been under investigation for the treatment of several unmet medical needs, including acute lung injury/acute respiratory distress syndrome (ALI/ARDS) wherein siRNA may be implemented to modify the expression
Makhloufi Zoulikha +5 more
semanticscholar +1 more source
Redox Biology, 2021 Increasing lines of evidence identified that dexmedetomidine (DEX) exerted protective effects against sepsis-stimulated acute lung injury via anti-inflammation, anti-oxidation and anti-apoptosis. However, the mechanisms remain unclear.
Jia Shi +12 more
semanticscholar +1 more source
Nature Communications, 2021 Oxidative stress contributes to the pathogenesis of acute lung injury. Protein S-glutathionylation plays an important role in cellular antioxidant defense. Here we report that the expression of deglutathionylation enzyme Grx1 is decreased in the lungs of
Yuxian Guo +9 more
semanticscholar +1 more source
Research progress on the mechanism of ferroptosis in neonatal acute lung injury [PDF]
Jichu yixue yu linchuang, 2023 Acute lung injury is a common critical illness in neonates. Ferroptosis, a novel form of programmed cell death, plays an important role in the process of acute lung injury by regulating iron homeostasis, metabolism of amino acid and lipid peroxidation ...
CHU Xiaoyun, CAI Cheng
doaj +1 more source
Imaging of Acute Lung Injury [PDF]
Radiologic Clinics of North America, 2016 Acute lung injury (ALI) is the clinical syndrome associated with histopathologic diffuse alveolar damage. It is a common cause of acute respiratory symptoms and admission to the intensive care unit. Diagnosis of ALI is typically based on clinical and radiographic criteria; however, because these criteria can be nonspecific, diagnostic uncertainty is ...
Elicker, Brett M +3 more
openaire +4 more sources
Aging, 2020 Acute lung injury (ALI) is a syndrome associated with a high mortality rate. Nrf2 is a key regulator of intracellular oxidation homeostasis that plays a pivotal role in controlling lipid peroxidation, which is closely related to the process of ...
H. Dong +6 more
semanticscholar +1 more source
Gut-Lung Crosstalk in Sepsis-Induced Acute Lung Injury
Frontiers in Microbiology, 2021 Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common acute and severe cases of the respiratory system with complicated pathogenesis and high mortality.
Xin Zhou, Youxia Liao
semanticscholar +1 more source
EBioMedicine, 2016 Lysophosphatidic acid receptor 1 (LPA1) is a druggable target for treating pulmonary inflammatory diseases. However, the molecular regulation of LPA1 stability, a factor that critically impacts its biological activity, remains largely unknown.
Jing Zhao +6 more
doaj +1 more source
A Repurposed Drug Screen for Compounds Regulating Aquaporin 5 Stability in Lung Epithelial Cells
Frontiers in Pharmacology, 2022 Aquaporin 5 (AQP5) is expressed in several cell types in the lung and regulates water transport, which contributes to barrier function during injury and the composition of glandular secretions.
John Villandre +18 more
doaj +1 more source
Inflammatory Caspases Drive Pyroptosis in Acute Lung Injury
Frontiers in Pharmacology, 2021 Acute lung injury (ALI), a critical respiratory disorder that causes diffuse alveolar injury leads to high mortality rates with no effective treatment. ALI is characterized by varying degrees of ventilation/perfusion mismatch, severe hypoxemia, and poor ...
Bohao Liu +6 more
semanticscholar +1 more source