Results 151 to 160 of about 6,391 (198)

Multi‐Target Drug Design in Alzheimer's Disease Treatment: Emerging Technologies, Advantages, Challenges, and Limitations

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disorder, recognized as the most prevalent form of dementia. It is characterized by multiple pathological processes, including amyloid‐beta accumulation, neurofibrillary tangles, and neuroinflammation. The therapeutic efficacy of traditional single‐target drugs has been
Md Saad Hossain, Md Hamed Hussain
wiley   +1 more source

Hereditary Multiple Osteochondromas and Acute Lymphoblastic Leukemia: A Possible Role for EXT1 and EXT2 in Hematopoietic Malignancies

American Journal of Medical Genetics Part A, Volume 197, Issue 7, July 2025.
ABSTRACT Hereditary multiple osteochondromas (HMO) is an autosomal dominant disorder caused by heterozygous deleterious variants in the EXT1 or EXT2 genes. While the clinical core phenotype is well established and mainly consists of bone deformities, limb length discrepancies, multiple benign bone neoplasms, and increased risk of chondrosarcoma, the ...
Francesco Comisi, Carmela Fusco, Rosamaria Mura, Carla Cerruto, Leonardo D'Agruma, Salvatore Carnazzo, Marco Castori, Salvatore Savasta   +7 more
wiley   +1 more source

Narrative Review of Patient Cancer Tissue–Derived Zebrafish Xenograft Models for Evaluating Drug Sensitivity as an Avatar Model for Clinical Application

Cancer Medicine, Volume 14, Issue 13, July 2025.
ABSTRACT In the pursuit of optimal medical care, treatment selection based on the molecular analysis of genomes, transcriptomes, and proteomes has been explored; however, this approach relies on data from large patient groups, resulting in limited accuracy in predicting treatment efficacy.
Yusuke Sugino, Xin Bao, Takumi Kageyama, Sho Sekito, Shiori Miyachi, Takeshi Sasaki, Toshio Tanaka, Takahiro Inoue   +7 more
wiley   +1 more source

Measurable residual disease (MRD) as a surrogate end point for clinical drug approval in acute myeloid leukemia (AML): Perspectives from the MRD Partnership and Alliance in AML Clinical Treatment Consortium

Cancer, Volume 131, Issue 13, 1 July 2025.
Abstract Despite advances in acute myeloid leukemia (AML) treatment, significant unmet medical needs remain. Surrogate end points for overall survival can accelerate the approval of novel therapies. Measurable residual disease (MRD) is a promising surrogate end point candidate, providing a sensitive and quantitative assessment of disease burden ...
Michael Boyiadzis, Andrew H. Wei, Bruno Paiva, Sylvie D. Freeman, Gertjan Kaspers, Brenda Chyla, Sarah Hersey, Reshma Patel, Brian Maloney, Marie‐Helene Blanchet Zumofen, Marlies Van Hoef, Beate Wulff, Vanessa Obourn, Shalaka Patel, Daniel Lopes de Menezes, Qian Shi, Bourras‐Rezki Bengoudifa, Natalie Dimier, Thomas J. Prior, Gail J. Roboz, Thomas Prebet   +20 more
wiley   +1 more source

ESR1 Variants and Subcontinental Genomic Ancestry: Insights from the 1000 Genomes Project and Native American Populations

Clinical Pharmacology &Therapeutics, Volume 118, Issue 1, Page 232-241, July 2025.
The ESR1 gene is relevant in breast cancer treatments in the pharmacogenetics context. However, Native, African, and mixed populations are known to be underrepresented in genomic studies. This is particularly important given that the difference in variants' frequencies among different populations can lead to population‐specific clinical implications ...
Mariana M. Scudeler, Caíque Manóchio, Bruno Miwa, Guilherme Belfort‐Almeida, Lucas Faria‐Costa, Cesar Sanchez, Carlos Padilla, Omar Caceres, Eduardo Tarazona‐Santos, Heinner Guio, Timothy D. O'Connor, Fernanda Rodrigues‐Soares   +11 more
wiley   +1 more source

T‐cell differentiation stage block bias confers hypermethylation and mediastinal preference in T‐cell lymphoblastic lymphoma

Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.
Malignant T cells in T‐cell lymphoblastic lymphoma (T‐LBL) are predominantly blocked in double negative (DN) and double positive (DP) stages. Block bias induces an immunosuppressive tumour microenvironment (TME) and mediastinal preference. Block bias upregulates UHRF1 leading to hypermethylation of tumour suppressor genes.
Jiali Wang, Bo Qian, Xiaowen Yu, Yidan Zhang, Chunlei Zhou, Tingting Yang, Le Xia, Gang Zhang, Yi‐Xuan Zhang, Yaping Wang, Yongjun Fang   +10 more
wiley   +1 more source

A Comparative Study of Bone Marrow and Central Nervous System Microenvironment Models to Improve In Vitro Studies of Acute Lymphoblastic Leukemia

Hematological Oncology, Volume 43, Issue 4, July 2025.
ABSTRACT The bone marrow (BM) niche plays a critical role in the development of acute lymphoblastic leukemia (ALL), while the central nervous system (CNS) is a common site of dissemination. Existing in vitro models of childhood ALL lack complexity and fail to recapitulate the in vivo microenvironments. This study aimed to improve ALL in vitro models by
Katrine Juhlin Kiørboe, Joana Serwaa Akoto, Morten Juhl Nørgaard, Merete Overgaard, Maria Niora, Krister Wennerberg, Kjeld Schmiegelow, Maria Thastrup   +7 more
wiley   +1 more source

Exposure to per‐ and polyfluoroalkyl substances in residential settled dust and risk of childhood acute lymphoblastic leukemia

International Journal of Cancer, Volume 157, Issue 1, Page 103-115, 1 July 2025.
What's new? Because of widespread use and resistance to degradation, per‐ and polyfluoroalkyl substances (PFAS) are ubiquitous in the environment. For young children, owing in part to crawling and hand‐to‐mouth behaviors, PFAS exposure is unique. Here, the authors investigated the risk of childhood leukemia in relation to PFAS found in settled dust ...
Catherine Metayer, Libby M. Morimoto, Veronica M. Vieira, Krystal J. Godri Pollitt, Scott M. Bartell, Luann Wong, Thomas M. Young   +6 more
wiley   +1 more source

Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Tumor cells adapt to nutrient‐poor environments by altering metabolism to acquire essential nutrients. They convert glutamine into glutamate and α‐ketoglutarate, supporting mTOR activation and sugar biosynthesis. Disruption of mTORC1 signaling is linked to disease, while glutamine and leucine activation promotes cell growth and inhibits autophagy ...
Mudasir A. Kumar, Sana Khurshid Baba, Inamu Rashid Khan, Mohd Shahnawaz Khan, Fohad Mabood Husain, Saheem Ahmad, Mohammad Haris, Mayank Singh, Ammira S. Al‐Shabeeb Akil, Muzafar A. Macha, Ajaz A. Bhat   +10 more
wiley   +1 more source

Small Nucleolar RNAs: Biological Functions and Diseases

MedComm, Volume 6, Issue 7, July 2025.
The majority of snoRNAs are derived from the intron region of genes, besides to intronic snoRNAs, some snoRNAs are transcribed as independent genes, often by Pol II or III, these snoRNAs are called intergenic snoRNAs. All of these play a role in the occurrence and progression of various diseases through multiple functions.
Yi Wang, Min Fu, Zaiyong Zheng, Jianguo Feng, Chunxiang Zhang   +4 more
wiley   +1 more source