Results 11 to 20 of about 132,496 (204)

Overcoming steroid resistance in T cell acute lymphoblastic leukemia [PDF]

, 2016
In a Perspective, Pieter Van Vlierberghe and Steven Goossens discuss Meijerink and colleagues' findings on steroid resistance in pediatric T cell acute lymphoblastic ...
Goossens, Steven, Van Vlierberghe, Pieter   +1 more
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Acute Lymphoblastic Leukemia in Children [PDF]

New England Journal of Medicine, 2015
The most common cancer in childhood is now curable in 90% of patients. Current efforts are focused on devising molecular-based therapy for the subsets of acute lymphoblastic leukemia that are most resistant to current therapy.
Hunger, S.P., Mullighan, C.G.
openaire   +4 more sources

Rationale for an international consortium to study inherited genetic susceptibility to childhood acute lymphoblastic leukemia

Haematologica, 2011
Acute lymphoblastic leukemia is the major pediatric cancer in developed countries. To date most association studies of acute lymphoblastic leukemia have been based on the candidate gene approach and have evaluated a restricted number of polymorphisms ...
Amy L. Sherborne, Kari Hemminki, Rajiv Kumar, Claus R. Bartram, Martin Stanulla, Martin Schrappe, Eleni Petridou, Ágnes F. Semsei, Csaba Szalai, Daniel Sinnett, Maja Krajinovic, Jasmine Healy, Marina Lanciotti, Carlo Dufour, Stefania Indaco, Eman A El-Ghouroury, Ruchchadol Sawangpanich, Suradej Hongeng, Samart Pakakasama, Anna Gonzalez-Neira, Evelia L. Ugarte, Valeria P. Leal, Juan P.M. Espinoza, Azza M. Kamel, Gamal T.A. Ebid, Eman R. Radwan, Serap Yalin, Erdinc Yalin, Mehmet Berkoz, Jill Simpson, Eve Roman, Tracy Lightfoot, Fay J. Hosking, Jayaram Vijayakrishnan, Mel Greaves, Richard S. Houlston   +35 more
doaj   +1 more source

Features of Pavement Damage due to Hyogo-ken Nanbu Earthquake [PDF]

, 1997
Translocation of the LYL1 oncogene are rare in T-cell acute lymphoblastic leukemia, whereas the homologous TAL1 gene is rearranged in approximately 20% of patients.
Buijs-Gladdines, Jessica, Homminga, Irene, Langerak, Anton, Meijerink, Jules, Pieters, Rob, Vuerhard, Maartje   +5 more
core   +3 more sources

Treatment of Adult Patients with Relapsed/Refractory B-Cell Philadelphia-Negative Acute Lymphoblastic Leukemia [PDF]

, 2019
The majority of adult patients affected by B-cell acute lymphoblastic leukemia (B-ALL) will relapse after an initial response, while approximately 20% will display primary resistant disease. Patients suffering from relapsed/refractory B-ALL have a very
Lanza, Francesco, Maffini, Enrico, Saraceni, Francesco   +2 more
core   +1 more source

Pediatric acute lymphoblastic leukemia

Haematologica, 2020
The last decade has witnessed great advances in our understanding of the genetic and biological basis of childhood acute lymphoblastic leukemia (ALL), the development of experimental models to probe mechanisms and evaluate new therapies, and the development of more efficacious treatment stratification.
Charles G. Mullighan, Hiroto Inaba
openaire   +5 more sources

MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia

Haematologica, 2014
T-cell acute lymphoblastic leukemia arises from the leukemic transformation of developing thymocytes and results from cooperative genetic lesions. Inactivation of the PHF6 gene is frequently observed in T-cell acute lymphoblastic leukemia, suggesting an ...
Evelien Mets, Gert Van Peer, Joni Van der Meulen, Michael Boice, Tom Taghon, Steven Goossens, Pieter Mestdagh, Yves Benoit, Barbara De Moerloose, Nadine Van Roy, Bruce Poppe, Jo Vandesompele, Hans-Guido Wendel, Pieter Van Vlierberghe, Frank Speleman, Pieter Rondou   +15 more
doaj   +1 more source

Oral health management in children with acute lymphoblastic leukemia

口腔疾病防治, 2021
Acute lymphoblastic leukemia is the most common type of leukemia in children. In recent years, the treatment and prognosis of acute lymphoblastic leukemia in children have improved significantly. However, acute lymphoblastic leukemia itself and treatment
TANG Yawen, ZHANG Lin, YANG Xue, ZOU Jing, WANG Yan   +4 more
doaj   +1 more source

The molecular basis of T cell acute lymphoblastic leukemia [PDF]

, 2012
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and ...
Adolfo Ferrando, Bash, Bash, Chen, Condorelli, Dube, Fisch, Hagemeijer, Hebert, Ho, Kelliher, Kikuchi, Larson, Lu, McGuire, McGuire, Nagel, Ntziachristos, Ntziachristos, Ono, Pieter Van Vlierberghe, Royer-Pokora, Rubnitz, van Grotel   +23 more
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Therapy-related acute lymphoblastic leukemia has distinct clinical and cytogenetic features compared to de novo acute lymphoblastic leukemia, but outcomes are comparable in transplanted patients

Haematologica, 2018
Therapy-related acute lymphoblastic leukemia remains poorly defined due to a lack of large data sets recognizing the defining characteristics of this entity.
Ibrahim Aldoss, Tracey Stiller, Ni-Chun Tsai, Joo Y. Song, Thai Cao, N. Achini Bandara, Amandeep Salhotra, Samer Khaled, Ahmed Aribi, Monzr M. Al Malki, Matthew Mei, Haris Ali, Ricardo Spielberger, Margaret O’Donnell, David Snyder, Thomas Slavin, Ryotaro Nakamura, Anthony S. Stein, Stephen J. Forman, Guido Marcucci, Vinod Pullarkat   +20 more
doaj   +1 more source